For WallyEJones and any1 else interested in ultra low dose

I had my Derm appointment today, and i showed him the article about the low dose and ultra low dose accutane from the dermetologytimes website.
He read it with interest and his first comment was:

In France they’v made it illigal for doctors to prescribe low doses of accutane over long periods, which is basically what the study suggests.
There is no proof, and no studies to show that long term use of this drug is safe.. or not.

I personally wouldnt take accutane for long periods, even if it is at 5mg per week or whatever

He said that if you were to treat your acne with ultra low dose accutane, you may get clear skin without side effects, but the acne would 100% come back as soon as you stop! so theres no point

On the other hand he was in favour of low dose accutane for people with not so severe acne, and those who have failed to respond to other medications (such as myself)

So i dunno.. make up your own mind..

I would think long term use of accutane could be harmfull and useless

Related Acne Archive Posts & Questions

4 thoughts on “For WallyEJones and any1 else interested in ultra low dose

  1. The thing is that many people with acne have something wrong with some gen that gives you very low amount oh P450 enzyme. P450 is responsible for A-vitamin metabolism and the creation of 13-cis retionic. So if you take ultra low dose av accutane you just normalize your level och 13-cis retionic acid.

  2. Thanks Pure. That is interesting, especially about the French banning it, but then again they are the French….. I wouldn’t mind having to take it for a long time, but I think you would need to have blood tests regularly. It is questionable with no prior experience though.

    Gustav, can you elaborate more on this P450? I’ve never heard of it before. Where is it stored?

  3. Retoninic acid is a natural metabolite of vitamin A that cannot be converted to retinol. It would appear that acne patients have a defect in vitamin A metabolism.

    The skin of acne patients shows greater activity of 5 alpha reductase, an enzyme which converts testosterone to a more potent androgen – dihydrotestosterone. Cytochrome P450, a detoxifying enzyme can accelerate the destruction of this active androgen.

    The review summarizes new results concerned with several important issues in the treatment of patients with acne. The first section reviews studies which show that 13-cis retinoic acid, a molecule with strong biological activity but low binding affinity for retinoid receptors and cellular-binding proteins in sebocytes, undergoes rapid intracellular conversion to all-trans retinoic acid. This active metabolite exerts its actions on sebocyte gene expression by binding to the nuclear retinoic acid receptor rather than the retinoid X receptor. Importantly, 13-cis retinoic acid, unlike all-trans retinoic acid, does not induce cytochrome P450 1A1, an enzyme responsible for the metabolism of xenobiotics. Thus, administration of 13-cis retinoic acid permits high long-term intracellular accumulation of its active metabolite

    Xenobiotic = Natural substances that are foreign to the body.

  4. Humans have 18 families of cytochrome P450 genes and 43 subfamilies
    CYP26A retinoic acid hydroxylase important in development (1 subfamily member)
    CYP26B probable retinoic acid hydroxylase (1 subfamily member)
    CYP26C probabvle retinoic acid hydroxylase (1 subfamily member)

    hydroxylase = enzyme

Comments are closed.