Retin-A stops acne, removes scar tissue, increases collagen

Retin-A, and Retin-A micro gel plus the other true and synthetic forms of Retinoic Acid are applied topically to stop acne, remove scar tissue through flaking of the surface skin, and also encourage faster collagen replacement under the surface of the skin. Retinoic Acid works on both the surface of the skin and deep inside the layers of the skin to change the actual structure of the skin.

Retin-A is Tretinoin while Isotretinoin is synthetic Tretinoin, all come from Retinoic Acid or are synthesized to be the same chemically as Retinoic Acid, plus Accutane and Roaccutane are formulated from Retinoic Acid, which is derived from Vitamin A. The name of the product just depends on what country you live in for the particular product name to be available for you to purchase. All are forms of Retinoic Acid in either the topical form or the systemic form, and all work in or on the body in the same way. The cautions are the same too for the topical and the systemic forms of Retinoic Acid. Wither synthetic or ‘true’ all are Retinoic Acid.

Please read the complete links as well as the commentary I have provided below.

Tretinoin (Retin-A) and Isotretinoin (Isotrex gel), are just two of the TOPICALS that are available, there are other topicals from the same chemical, while Accutane is the SYSTEMIC (oral) version of the same chemical derived from Vitamin A. I don’t mind going through this exercise AGAIN with you, Luvhause, as we do have new posters to this board who may not understand how Accutane, Retin-A, Retin-A gel, Isotretinoin, Isotrex gel, and Roaccutane, plus several other forms of Retinoic Acid are all related because they are all Retinoic Acid, either natural or synthetic.

http://www.emedicine.com/derm/topic151.htm

Isotretinoin (Accutane) — Oral agent that treats serious dermatologic conditions. Isotretinoin is the synthetic 13-cis isomer of the naturally occurring tretinoin (trans-retinoic acid). Both agents are structurally related to vitamin A.

The above site is probably the best site for anyone who is considering using a Retinoic Acid product for their skin to either eliminate acne or to reduce/remove scar tissue. I highly recommend that everyone do a read-through of this web site from emedicine.
solomio

http://www.dermnetnz.org/index.html

Topical Retinoids

The group of medicines known as retinoids are derived from Vitamin A. Creams containing the retinoids retinol and retinaldehyde can be obtained over the counter at pharmacies and supermarkets. Other topical retinoids containing tretinoin or isotretinoin require a doctor’s prescription. Adapalene is a related prescription medicine.
Topical retinoids can be applied to any area but are most often used on the face, the neck and the back of hands.
There are many brand name face creams that contain retinol or retinaldehyde, which are quite well tolerated and may help improve the appearance of aging skin. The trade names of the more potent topical retinoids available on prescription in New Zealand are:
· Retin-A Cream (tretinoin)
· Isotrex Gel (isotretinoin)
· Differin Gel, Cream (adapelene)
· Retinova Cream (tretinoin emollient), specially formulated for ageing skin.

Isotrex Gel is the TRADE NAME for Isotretinoin, which is a synthetic , and is chemically the same as Tretinoin while Tretinoin is the name that Retin-A is marketed under, in the United States. Both are Retinoic Acid and are topicals while Accutane is the systemic.

http://bnf.org/bnf/bnf/current/doc/6048.htm

Note.
Isotretinoin is an isomer of tretinoin
Sub-sections

Isotretinoin
Roaccutane®

Topical Isotretinoin is Isotrex gel plus Isotretinoin is also used as the synthetic systematic, oral Accutane which is sometimes administered in place of Roaccutane. Roaccutane is true Accutane but is just the name used in Europe for what we call Accutane in the U.S. In the U.S. we have Accutane as the ‘true’ retinoid for oral administration and we have several creams that are topical Accutane among these creams is Retin-A. We also have the micro gel form as a topical, which is true Retinoic acid but is time released, and often prefered by people who have active acne. I believe that the micro gel form of Retin-A is also available in Europe.

http://www.pharmacynetworkgroup.com/c/accutane-pharmacology.htm

Metabolism: After oral administration of isotretinoin, 4- oxo -isotretinoin is the major metabolite identified in the blood. Maximum concentrations of 4- oxo -isotretinoin (87 to 399 ng/mL) were achieved at 6 to 20 hours after oral administration of two 40-mg capsules; the blood concentration of the major metabolite generally exceeded that of isotretinoin after 6 hours. Isotretinoin also undergoes isomerization to the all-trans-isomer, tretinoin, which is then metabolized to its corresponding 4- oxo -metabolite; both have been detected. Both parent compound and metabolites are further metabolized into conjugates which are excreted.

Here in the above link to a Mexican pharmacy; synthetic Isotretinoin is the preferred form of oral, systemic Retinoic Acid that is dispensed here. True oral, systemic Retinoic Acid would be called Accutane or Roaccutane as it is called in Europe. We already know, from reading, that Isotretinoin is a synthetic Tretinoin perhaps that is why this pharmacy uses it for the oral administration as it is most likely much cheaper to use than the ‘real thing.’
BRAND NAMES also play a part in the naming of this chemical that we know in the United States as Accutane for the systemic oral, and as Retin-A or Retin-A micro gel for the topical. We also have versions of Retin-A that are synthetic, and at least one brand that I have read about that has an antibiotic included in with the topical product.

http://fbdr.hsc.usf.edu/professional/advisories/accutane.html

Advisories:
Accutane
Accutane (isotretinoin) is the 13-cis isomer of tretinoin, the naturally occurring form of retinoic acid. It is used for the treatment of severe, recalcitrant cystic acne. Accutane has been described as one of the most potent teratogens known to man and its teratogenicity has been well documented in both human and animal studies.

Retin-A is topical, true Retinoic Acid; Accutane is the oral, true Retinoic Acid; and both are the common forms available in the U.S.
Retin-A is also available in the U.K.
Isotrex gel is a synthetic, topical retinoid; Isotretinoin is the synthetic oral retinoid that is related to Isotrex; and both are available in Europe and I believe in the rest of the world.
Roaccutane is true Retinoic acid, and is the same as Accutane. Roaccutane is available in Europe and in the rest of the world.

Solomio

Related Acne Archive Posts & Questions

21 thoughts on “Retin-A stops acne, removes scar tissue, increases collagen

  1. Hey, great thread Solomio 😀 😀 😀

    I’m using Isotrex which is by prescription only from a GP (family doc) so it only costs £6/7 a tube. It’s .05% and that’s as strong as is available in the UK. Havene’t been able to source retin-a micro – or anything that is .1% – I would like to move up to a higher % now as the Isotrex doesn’t peel me at all any more. Any suggestions as to how I could get my hands on the retin-a micro .1% in the UK? Thanks :mrgreen

  2. I WAS PRESCRBED RETIN A BY BY GP
    ITS WIDELY AVAILABLE HERE
    I NEVER USED IT THOUGH

    SOLOMIO, GRET INFO
    I HAVE READ A LOT OF GOOD THINGS ABOUT COPPER PEPTITE AND HOW ITS MORE POWERFULL AS RETIN A
    WHAT DO U THINK ABOUT COPPER PEPTITE?

  3. Retin A is SLOWLY evening out SOME of my skin and the red spots are fading, though they haven’t gone overnight!

  4. Solomio,
    Do you use the Gel or the Cream form?
    I’ve been given Retin-A cream, because I’ve used Istorexin in the past, but it burnt my skin badly. The Derm seems to think that the cream will be gentler for me; it’s 0.025%.
    The reason I ask is because Maya, (Hi Maya! :wave ), mentioned that the cream can be pore clogging for some people.
    Any thoughts?
    Also, I was advised to use Retin A only every third night to begin with working my way up to every night, and also to use only a pea-sized amount mixed 4 to 1 with my normal moisturiser.
    Your knowledge would, as always, be very much appreciated.
    Emma.

  5. Hi Emma :rock

    Hey Solomio – I was wondering… Just had some excision (12 in total) on my face, I’m just using emu oil at the moment, but do you think I could put my Isotrex on yet? Or should I wait till the stitches get removed next week?

  6. Maya,
    I don’t know if you should put the Isotrex on the newly forming skin that is closing your excisions. If I were to say go ahead, and you should have a problem later on I would feel terrible about it. I would feel it was my fault that you had a problem. Deep down I think it might help speed up the healing process but is that a good thing to do??????

    What does Dr. Chu think you should do?

    I am very curious about this process. I read your description, on your scar board last night, of how your holes became tiny incision lines, and it all sounds so hopeful for so many people!
    Solomio

  7. Purepersian,
    I ordered Copper Peptides long before I came to this forum but because of the smell it has, I never used the product. Now I wish I had used it bcause it is collagen encouraging. I still have the bottle but am not sure if it is still good?
    Solomio

  8. Hi Emma,
    Retin-A cream contains Isopropyl Myristate.
    I don’t have a problem with this chemical but some people have reacted to it by breaking out. Lord knows WHY the drug company would use such a chemical in a product used by people who have acne, I will never know.

    My doc told me to not mix the cream with a moisturizer for 2 reasons. First, your skin should be bone dry when you apply Retin-A cream to it. The water in the moisturizer could cause you to react to the retinoic acid, and have your skin turn red, this is mainly because of the water content reacting badly with the acid. The other reason was that adding a product to the cream could cause it to neutralize before you apply it, and not work in the way it is supposed to work. Sometimes I add jojoba to my face an hour or so after applying the cream. This does not neutralize the retinoic acid and does not cause a problem because jojoba oil is actually a wax that is very much like natural sebum and for some reason it does not cause a problem when it is applied to the skin after the cream has sunk into the tissues.

    If you have a bad reaction to mixing your own moisturizer into the cream, by bad reaction I mean if you should turn red and get peely, you might want to ask your doctor for Renova. Renova is regular Retin-A cream with the moisturizer mixed into the cream in the lab before it is packaged. I guess they use a certain formula for the moisturizer that does NOT cause a problem in Renova.

    Solomio

  9. Maya,
    I don’t know if you should put the Isotrex on the newly forming skin that is closing your excisions. If I were to say go ahead, and you should have a problem later on I would feel terrible about it. I would feel it was my fault that you had a problem. Deep down I think it might help speed up the healing process but is that a good thing to do??????

    What does Dr. Chu think you should do?

    I am very curious about this process. I read your description, on your scar board last night, of how your holes became tiny incision lines, and it all sounds so hopeful for so many people!
    Solomio

    I did start using the Isotrex after the stitches came out – it’s helping.

    I’ll update all my excision experience on this board shortly for this board to see – couldn’t log in for a few days as I hadn’t realised that the board had changed name! :crazyeyes

  10. I have been using isotrex gel over a year. I have never found any possitive effects from it aside from a slight decrease in the oiliness of my skin. It didn’t help my acne, just made it worse for the first few months I was on it.

  11. Solomio,
    Sorry I haven’t seen your reply to me for some time. :oops….many thanks!
    Funnily enought Retin-A hasn’t peeled me at all, or made me red in the slightest. I wonder if it’s because I’ve been using my moisturiser? Or as you mentioned, perhaps I am neturalising the effects by adding moisturiser?
    Maybe then, I should try just using Retin A at night and only moisurise in the morning?
    I wonder too whether I need a higher strength of Retin-A?
    I’m very confused.
    A few people have mentioned though, that my skin looks smoother, and I’ve noticed a very slight improvement in my red marks….perhaps I’m just moisturising so well that I’m not even noticing the peeling?
    I’m also considering trying the Mandelic Serum that so many people seem to be having success with….Maya and Tracey seem to be converts!!

    There are so many options and things to try….it all gets very confusing doesn’t it!

    Thanks again Solo,
    Emma.

  12. Maya do you have any pictures of your scars and how they are progressing?
    I am really interested in your progress

  13. Emma, I have recently discovered that I was somewhat neutralizing my Retin A effects by putting copper peptides first. I finally figured out that the copper peptides need to go on AFTER the Retin A. I put on the Retin A micro, wait a half hour, then put on copper peptides. I then wait another half hour and put on a homemade alpha lipoic acid solution. This seems to be working fantastic on scars and redmarks. I could be wrong, but I think you’ll be ok to use moisterizer as long as you put the Retin A on first, then wait for a while to put on anything else.

  14. Emma, I have recently discovered that I was somewhat neutralizing my Retin A effects by putting copper peptides first. I finally figured out that the copper peptides need to go on AFTER the Retin A. I put on the Retin A micro, wait a half hour, then put on copper peptides. I then wait another half hour and put on a homemade alpha lipoic acid solution. This seems to be working fantastic on scars and redmarks. I could be wrong, but I think you’ll be ok to use moisterizer as long as you put the Retin A on first, then wait for a while to put on anything else.

    homemade alpha lipoic acid solution???
    Could you tell me how you made this? As i want to do it too
    lol
    thanks

  15. Denise,
    Many thanks for your tip; I’ll give it a try.
    For the past couple of nights I’ve been only using Retin-A and moisturising only in the morning.
    So many things to try…..and so inpatient!!
    Thanks Again.

  16. I have been mixing my copper peptides with my Retin-A micro gel. I seem to be getting pretty good results this way, so I assume one doesn’t neutralize the other. The leaflet I received with the Super Copper Peptides from homepeels suggested mixing the two.

  17. I’m sorry Wally, I haven’t been to the board in some time. Things are still going well mixing the copper peptides and the Retin-A. My scars seem to be improving much more than with the Retin-A alone. Or at least I think so…I hope it isn’t my imagination. Have you tried mixing them?

  18. I havent mixed them. I haven’t really been putting much on my redmarks and scars, though I think I might. I’m thinking about trying out mandelic acid.

  19. My red marks are pretty much gone except for a very few. I am obsessed however, with getting rid of as much scarring as I can before I pay for microdermabrasion and the like. I think I’ll try the mandelic as soon as I am out of my glycolic products, everyone seems to like them so much. If you start using it, keep me posted on your progress.

    Are you still using Retin-A?

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