Sorry for the english
This thread isn’t some rambling on how Accutane can have some bad side effects, it just show how Accutane works and you’ll have to decide whether you’ll take it or not.
In the Roche pamphlet it is stated that the EXACT mechanism of isotretinoin is unknown. This information isn’t all wrong, but the truth is that the mechanism of isotretinoin is pretty well known. It just hasn’t been proven 100 % by lab essays.
Well here are the hypothesis on how Roaccutane gets rids of acne. I’ll try to keep such a complex thing as simple as I can for everyone to understand.
Roaccutane (isotretinoin) is a synthetic retinoic acid. The body uses retinoic acids to regulate gene expression. Gene expression means the way that cells are created (simplified a lot). Cells to be created needs transcription and replication of DNA. To put it simple, it’s like making a cake. You need the ingredient list to be able to make the cake. The body needs DNA to be able to make the cells. Retinoic acids comes in this process by regulating the gene expression. It means that retinoic acid is a part of the creation of the cells. Retinoic acids binds to specific receptors in the body and play his role in the transcription and replication of DNA.
Here are some gene where retinoic acid play an important role (transcription and replication) :
Phosphoenol puryvate……………….Gluconeogenese (metabolism of sugar)
Alcohol dehydrogenase………………alcoholic oxidation
Transglutaminase……………………..Growth and death of the cells
Laminine B1…………………………….Cellular interaction
GLA matrix protein…………………….Growth and synthesis of the bones
Retinol binding protein type I………..Vitamin A metabolism
RAR……………………………………….. Vitaminic A action
HOX 1.6……………………………………fœtus growth
Dopamine receptor D2…………………CNS (central nervous system).
Why roaccutane heal acne :
Because Roaccutane and retinoic acid play a key role in the skin keratin gene. Acne is a keratin problem. So to fix acne you need to change the way DNA replicates for the keratin process to be brought to normal in patient with acne (having keratin problems). Roaccutane is the best known retinoic acid when it comes to keratin problems. So where is the problem with Accutane. Well the problem with Accutane is that unfortunaltely it doesn’t act only on the Keratin gene . It also act (to a lesser extent on all the genes That I named previously). Here comes the side effects.
We’ve seen that Accutane acts on the keratin gene. It changes the way it replicates. That’s why the people get dryer skin and no more acne, they also get peeling of the lips, hands, bleeding of the noose, dry scalp, dry skin, eye irritation. But these symptoms aren’t that harsh. And even if some stay long term it definitely isn’t a problem for acne sufferers. Accutane leaves in the cells receptors small traces of retinoic acids for very long term. That’s the reason Accutane is considered a permanent cure to acne. Very small amount of it (we’re talking about micrograms) are left on cells receptors for long term. that’s why even after cessation of the treatment the acne is still gone.
The other side effects.
Bone pain : this one comes from the change in the replication and transcription of the GLA matrix protein gene. Accutane affect this gene.
Low blood sugar : this one comes from the change in the replication and transcription of Phosphoenol pyruvate gene. Accutane affect this gene.
Teratogenicity (means messes with the foetus growth). This one comes from the change in the replication and transcription of the HOX 1,6 gene. Accutane affect this gene.
Insomnia, depression suicidal thoughts, muscle twitching….. This one comes from the change in the replication and transcription of the Dopamine receptor D2 gene. Accutane affects this gene.
Weight loss (unable to gain weight back), weight gain. This one comes from the change in the replication and transcription of the Growth hormone gene. Accutane affect this gene
And so on.
Now why do Accutane causes terrible side effects to some and not so terrible side effects to the most. There are mainly two reasons :
– Accutane is isotretinoin : a synthetic retinoic acid that is supposed to only affect the keratin gene. It does affect all the other genes but to a lesser extent.
– Once Accutane is introduced in the body, damage is starting to be done to the body. Cells dies at a greater rate or grow at an anarchic rate. Most of the people can repair the damage so the rate at which cells are repaired is greater than the rate at which cells are damaged. Remember that each day millions of cells are created and millions of cells are dying. It is the aging process. Accutane in some person illicit a greater damage rate and the body with time is no longer able to repair the damage at the same rate it is done. That’s why some people have reported side effects from Accutane years after they stopped the drug.
This is how roaccutane works for getting rid of acne and also how it illicit in some person terrible side effects. Once you have taken Accutane the way your DNA is Transcripted and replicated is modified, it is just like you are genetically modified. That’s why you don’t have acne anymore but bottom line, that’s why some experience terrible and devastating side effects.
Now that you know the whole truth about the drug, it is your choice to take it or not.
When I took the drug, I was unfortunately only 21 and I was more preoccupied on how I could get that girl sitting next to me in class going out with me. Like all 21 years old guys I wasn’t preoccupied by Retinoic acids and gene transcription (and to be honest those biology courses I was taking were boring). I would have wanted someone to warn me and tell me how Accutane really works. I wouldn’t be in such trouble now because knowing the whole truth about the tane, I would have never ever took it.
PS : for those that think that derms know everything about Accutane and that they wouldn’t prescribe it if it was a hazardous substance. Wake up, derms aren’t biologists or chemist. They aren’t some smart brains. The only ability they have is a learning one. They are unable to use logic and mathematic to understand how roaccutane works, go ask them by wich chemical route Accutane is made, they will not answer because they know nothing about the drug. It took me Thousand of pages before starting to understand how the accutane works. Also I don’t want to sound to pretentious but most of my teacher always been amazed how fast and how easy I was always to understand hard stuff. Hell, sometimes I was explaining to the whole class maths problems because the professor was unable to explain it or even to solve it. Accutane causes side effects that no doctor has ever seen and they can’t cure them because they are not like the symptoms they know. Accutane side effects will mimic other disease but the doctors don’t know it so they can’t cure them. You are warned.
Please if your acne isn’t severe and if you don’t think about suicide stay away of this drug.