ACCUTANE, TAKE IT OR NOT ??????

Sorry for the english

This thread isn’t some rambling on how Accutane can have some bad side effects, it just show how Accutane works and you’ll have to decide whether you’ll take it or not.

In the Roche pamphlet it is stated that the EXACT mechanism of isotretinoin is unknown. This information isn’t all wrong, but the truth is that the mechanism of isotretinoin is pretty well known. It just hasn’t been proven 100 % by lab essays.

Well here are the hypothesis on how Roaccutane gets rids of acne. I’ll try to keep such a complex thing as simple as I can for everyone to understand.

Roaccutane (isotretinoin) is a synthetic retinoic acid. The body uses retinoic acids to regulate gene expression. Gene expression means the way that cells are created (simplified a lot). Cells to be created needs transcription and replication of DNA. To put it simple, it’s like making a cake. You need the ingredient list to be able to make the cake. The body needs DNA to be able to make the cells. Retinoic acids comes in this process by regulating the gene expression. It means that retinoic acid is a part of the creation of the cells. Retinoic acids binds to specific receptors in the body and play his role in the transcription and replication of DNA.

Here are some gene where retinoic acid play an important role (transcription and replication) :

Gene

Oxyticine………………………………..reproduction
Growth hormone………………………Growth
Phosphoenol puryvate……………….Gluconeogenese (metabolism of sugar)
Alcohol dehydrogenase………………alcoholic oxidation
Transglutaminase……………………..Growth and death of the cells
Laminine B1…………………………….Cellular interaction
GLA matrix protein…………………….Growth and synthesis of the bones
Keratin……………………………………Skin
Retinol binding protein type I………..Vitamin A metabolism
RAR……………………………………….. Vitaminic A action
HOX 1.6……………………………………fœtus growth
Dopamine receptor D2…………………CNS (central nervous system).

Why roaccutane heal acne :

Because Roaccutane and retinoic acid play a key role in the skin keratin gene. Acne is a keratin problem. So to fix acne you need to change the way DNA replicates for the keratin process to be brought to normal in patient with acne (having keratin problems). Roaccutane is the best known retinoic acid when it comes to keratin problems. So where is the problem with Accutane. Well the problem with Accutane is that unfortunaltely it doesn’t act only on the Keratin gene . It also act (to a lesser extent on all the genes That I named previously). Here comes the side effects.

We’ve seen that Accutane acts on the keratin gene. It changes the way it replicates. That’s why the people get dryer skin and no more acne, they also get peeling of the lips, hands, bleeding of the noose, dry scalp, dry skin, eye irritation. But these symptoms aren’t that harsh. And even if some stay long term it definitely isn’t a problem for acne sufferers. Accutane leaves in the cells receptors small traces of retinoic acids for very long term. That’s the reason Accutane is considered a permanent cure to acne. Very small amount of it (we’re talking about micrograms) are left on cells receptors for long term. that’s why even after cessation of the treatment the acne is still gone.

The other side effects.

Bone pain : this one comes from the change in the replication and transcription of the GLA matrix protein gene. Accutane affect this gene.

Low blood sugar : this one comes from the change in the replication and transcription of Phosphoenol pyruvate gene. Accutane affect this gene.

Teratogenicity (means messes with the foetus growth). This one comes from the change in the replication and transcription of the HOX 1,6 gene. Accutane affect this gene.

Insomnia, depression suicidal thoughts, muscle twitching….. This one comes from the change in the replication and transcription of the Dopamine receptor D2 gene. Accutane affects this gene.

Weight loss (unable to gain weight back), weight gain. This one comes from the change in the replication and transcription of the Growth hormone gene. Accutane affect this gene

And so on.

Now why do Accutane causes terrible side effects to some and not so terrible side effects to the most. There are mainly two reasons :

– Accutane is isotretinoin : a synthetic retinoic acid that is supposed to only affect the keratin gene. It does affect all the other genes but to a lesser extent.

– Once Accutane is introduced in the body, damage is starting to be done to the body. Cells dies at a greater rate or grow at an anarchic rate. Most of the people can repair the damage so the rate at which cells are repaired is greater than the rate at which cells are damaged. Remember that each day millions of cells are created and millions of cells are dying. It is the aging process. Accutane in some person illicit a greater damage rate and the body with time is no longer able to repair the damage at the same rate it is done. That’s why some people have reported side effects from Accutane years after they stopped the drug.

This is how roaccutane works for getting rid of acne and also how it illicit in some person terrible side effects. Once you have taken Accutane the way your DNA is Transcripted and replicated is modified, it is just like you are genetically modified. That’s why you don’t have acne anymore but bottom line, that’s why some experience terrible and devastating side effects.

Now that you know the whole truth about the drug, it is your choice to take it or not.

When I took the drug, I was unfortunately only 21 and I was more preoccupied on how I could get that girl sitting next to me in class going out with me. Like all 21 years old guys I wasn’t preoccupied by Retinoic acids and gene transcription (and to be honest those biology courses I was taking were boring). I would have wanted someone to warn me and tell me how Accutane really works. I wouldn’t be in such trouble now because knowing the whole truth about the tane, I would have never ever took it.

PS : for those that think that derms know everything about Accutane and that they wouldn’t prescribe it if it was a hazardous substance. Wake up, derms aren’t biologists or chemist. They aren’t some smart brains. The only ability they have is a learning one. They are unable to use logic and mathematic to understand how roaccutane works, go ask them by wich chemical route Accutane is made, they will not answer because they know nothing about the drug. It took me Thousand of pages before starting to understand how the accutane works. Also I don’t want to sound to pretentious but most of my teacher always been amazed how fast and how easy I was always to understand hard stuff. Hell, sometimes I was explaining to the whole class maths problems because the professor was unable to explain it or even to solve it. Accutane causes side effects that no doctor has ever seen and they can’t cure them because they are not like the symptoms they know. Accutane side effects will mimic other disease but the doctors don’t know it so they can’t cure them. You are warned.

Please if your acne isn’t severe and if you don’t think about suicide stay away of this drug.

Related Acne Archive Posts & Questions

52 thoughts on “ACCUTANE, TAKE IT OR NOT ??????

  1. permanent side effects happens more than one can think.

    here are some PM/emails I got from accutane sufferes. I erased the name on them so I don’t think the senders will be angry at me for posting them. I received a lot more than that but I had to erase most of them due to lack of space. I gives a nice site of accutane adverse effects. nasty side effects occurs more than roche is willing to accept

    Hi
    i’m *******. im 18 and took accutane a year ago (almost)and have disgusting amounts of hairloss. if i do the ponytail test it seems to me like i have lost atleast 50-60% of my hair. not the worest case ever im sure, but seems like this isn’t about to stop so it’ll get worse. anyway, i was just wondering about the richard evans treament. have you heard anything new about it? i’m pretty much to the point where i will try anything. this whole thing with the acne than the hairloss right after has made me so depressed, i feel like if i can’t find something to stop it then there is really no point of living. i could deal with this maybe if it all fell out right away or if i knew a timespane, but since there are no answers i fell like im being tortured. if this could help me i would gladly hand over the money, but i need to know if it works. anything you can tell me would be great. sorry for venting this on you.
    thanks in advance

    Hi Mod
    I have been reading your posts with interest and sometimes amusement…your bad moods remind me of my ex-bf who was majorly intelligent and funny but a pain in the ass to be around some days haha!! The reason for this correspondence is that your personal research into depleating the body via eliminating certain foods interests me. The main reason for me trying this is probably because I am so DESPERATE to do anything that might help me feel better that a snake oil salesman could con me right now given half a chance and a half plausable theroy! So yours, which seems to have a reasonable foundation to it appeals to me. Anyway I feel that you are onto something and I have been to some websites to check the nutrient content of some fruits and vegetables and noticed you telling ****** that potatoes and rice and pasta, the home made bread, red meat and chicken and not much else can be eaten. I saw that mushrooms and onions and yams and turnips have no Vit A as well as garlic which you have mentioned. Also, flaxseed and sunflower seeds. I tried in vain to find one pathetic fruit without Vit A to no avail. I have terrible constipation so my bowel issues are different to a lot of people here, so what I need to know is how long you would go onto a rigid diet excluding all foods except the above mentioned? Or have I included some that you would not eat for some reason? What about black coffee and tea and also diet drinks such as coke and pepsi being used? What about salt and sugar being used? Have you heard of stevia which is a natural sweetner but I dont know the breakdown of the product and use it instead of suagar to keep my weight down as I have Poly Cystic Ovaries as well as this feral poisoning and need to eat a low GI diet..this eating plan kind of throws that out of the window with the high carb content but my overall health takes priority over the size of I disagree to be honest. Any help you would be able to offer would be appreciated.
    thanks and regards

    hey mod thanks for the prayers… i will take all positive energy anyone is prepared to send my ways. thanks so much for thinking of me when you have your own problems…this is really tiring isnt it… its so crappy for people to have to come and talk about this stuff instead of meeting in a chat room and just having some fun..but it is nice to even be light in here sometimes because its so heavy and nutsty living it all the time day in day out.
    take care and all the best
    hey if you have hotmail and want to be added to my messenger let me know your address …if not we can chat in here from time to time and thats fine

    Hi mod i just talked to ********…I am not easily sold and I think this is legit.He just understands too much to be bluffing. I have suffered 19yrs. and he is the first person that understands where our heads are at b/c he has been there. It makes sense! It seems that we need some special attention on so many biochemical and psycological levels that we have to ******** will be there soon. and he can tell us more…

    Hi Mod I think what your doing is awesome man! I first took Accutane in 84 and again in 89Yikes! I first realized i had some kind of food alergy in 90 (just felt like crap when i ate certain foods….the things Vit A your supposed to avoid when taking isotretinoin). I have always been health conscious. For 4 years when I lived on an organic farm I ate only things i had grown myself and things from some other organic farmers. I was onto the vit A thing and did my best to eliminate it from my diet. It seems to me that there was a definite relationship between my ibs,joint pain,and general well being. I believe that our condition is hepatic in function(related to liver ie: liver disorders are cyclic in nature…every six mos to a year you have a time when we are more sensitive). Have you noticed this? I have had seizures and numerous cysts that are not genetic and i know that they were caused by accutane. I have some of the best docs and have had numerous tests (Whole body MRI twice) Three of my sisters are lab techs and i work in a drug lab and can analize anything. I have noticed that i still really have to watch sun exposure…i think it is a major trigger..(vit D makes A and so on..) I am very interested in knowing more about this liquid diet that you are on but i cant find a weight gain supp.with no vit A or lisene. There is a red meat connection and it is one of the only things that makes me feel normal …..Spinach and yams and some oils are the worst and oh ya liver of any kind YIKES! Dairy is a given and the proccessed foods are too but i cant seem to find out what is in em (analized all sorts of strange things for content) Some food colourings have vits and parabens they are very scary; gummy bears,jelly beans. Also I have access to purified water and your right with the bottled water only theory just watch its content. Anyways Mod I gotta go now stay focused and positive and PM me back……….i really dont want to post as of yet…but i want more info on the suppliments you are taking….thanx

    Hi mod,
    I have read a couple of your posts regarding vitamin A injections and was curious about them. I have a vitamin A sensitivity as well after taking accutane. A couple of years ago I took an emulsified cod liver oil supplement endorsed by Roy Alexander. I was able to tolerate it but a year ago he died and I can’t find it any more. How often and where do you get the injections ? Is it through your doctor ? Does it help you physically ? You see I lost 25 pounds while on accutane and can’t gain weight anymore. I’m not sure if it is because I can’t metabolize vitamin A or fat or what ? Did you lose weight on accutane ? YOu said you now weight 192. What did you weigh before ? I am 6″2 and weigh only 150 pounds. I weighed 175 when I was 24 years old. I am now 35 years old.

    Hi Mod,

    I haven’t been on the Accutane Active group for very long, but I’ve enjoyed reading your posts.
    I’m sorry you had to suffer so much with IBS. Fortunately, this is one accutane side effect I was lucky enough to avoid. My problems have affected my musculoskeletal system.
    I went on the tane in 1996 and have been suffering ever since. The last 3 years, however, the side effects have been improving very gradually. I won’t bore you with my sob story, but I’ve been through 3 lots of surgery and lots of pain. I no longer suffer from bone pain, but still have a lot of inflammation in my muscles.
    Three months ago, I dramatically cut down my Vit A consumption from food and my symptoms have improved more during this time than in the last 3 years. Over the last 7 years, my diet has been extremely high in vegetables, especially carrots. I had no idea that I was worsening my symptoms by heaping more Vit A into my system.
    I still eat celery, spring onions, peas, lettuce, cabbage and potato. I’m pretty sure that these vegies don’t contain Vit A in any significant amounts. (If they do, please let me know).
    Over the last 3 years, I’ve also been taking various ‘natural’ supplements to help cut down the inflammation in my system. I don’t know how effective these have been, though, because I haven’t taken any supps for the last 3 months and, like I said, have felt better during this time than I have in a long time. Maybe all these supps were stressing my liver?
    I’m thinking about reintroducing glucosamine sulfate, grapeseed extract and ester c to help my joints.
    I’m also thinking about taking 400 IU of vitamin E. What do you think?
    I’d like to know what other things I should or should not take to help my muscular and joint problems.
    What foods and supplements do you think I should avoid? Will saturated fat increase my inflammation?
    I read about someone taking evening primrose oil with good results. How would that help?
    Should I be taking B complex vitamins, or will this stress the liver too much?

    Sorry to ask so many questions, but I think you’re a valuable source of information for tane sufferers and a great asset to the group. I’m asking you these questions now because you said that your No Vitamin A Diet post was probably your final.

    Hi Mod I have been following your progress in the forum and I am very happy
    for u that you seem to have found a strategy that works for you. Can you
    please tell me it. Also did you have hair loss if so has this diet helped ?
    I would also like to know your views on this ******** treatment as I am
    meant to be meeting him and ******** in London soon but I am very wary of being
    taken for a ride. I have emailed a scientist who believes it cant be done
    and the only way you can do it can be very toxic to a human.


    And I’m not talking about those I had a correspondance with that stopped because they comitted suicide as their side effects were too hard to bear.

  2. Geez…You shouldn’t post things like that. It scares the crap out of me and Im sure other people too.

  3. Geez…You shouldn’t post things like that. It scares the crap out of me and Im sure other people too.

    you are totally right, I shouldn’t, and I have been on the forum a long time without posting it, because I knew that it will scare people.

    But what do you prefer, be scared and know the truth or take the drug without knowing how it really works.

    For those who know me, I have never tried to scare people by my posts it is just the truth, the whole truth and nothing but the truth.

    It’s not some rambling about the danger of accutane, THIS IS SCIENCE. These are FACTS, not some experience from an accutane suffere, IT IS TRUTH.

    I have taken roaccutane myself and have suffered from it, but at no time I knew how the tane was working and how it was possible for this drug to do this kind of damage, but science explains it all.

  4. hmmm……….maybe some people should post positive thoughts to make this a little less biased

  5. hmmm……….maybe some people should post positive thoughts to make this a little less biased

    andy, we’re not talking about thoughts, we’re only talking about science and how roaccutane works, like I said I have been wondering if I had the right to post how roaccutane works because yes it is scary.

    Also I know that ROCHE do surf a lot of acne board on the net (for feedack), and the IP they use can be traced down to a roche.com domain. If one of the guys from roche disagree in what is in my post, I’ll be more than happy to discuss this with him. But he can’t disagree on truth :lol

  6. mod i hope u dont mind me asking… but you said you took accutane and are now suffering from its side effects…. what eactly has happened?

    is ur acne clear?

  7. mod i hope u dont mind me asking… but you said you took accutane and are now suffering from its side effects…. what eactly has happened?

    is ur acne clear?

    you can ask no problem, bro.

    Well at the end of the treatment I had severe diarrhoea, and huge weightloss. it was 3-4 years ago (times is pretty mixed on my head since then so I can say an excat date). I have been unable to get any kind of help from doctors because the side effects are so special, and so unknow. Anyway after hours of intense reading I have a diet that help me get my life back.

    I only eat powdered food (I import the m form UK and US).
    My vitamin mineral suplly comes from a custom made blend from a us pharmacist
    I can’t take vit A orally as it just messes with my bowels (I take every 20 days an IM injection of vit A).
    I had to exercise like crazy to get back what I used to be, I’m now 192 lbs and 6’2, but at the worst I was down to something 140 lbs (unable to gain weight even if eating like ten).

    I have to say that it took me three years to master those side effects, and I really can say with proud that nearly no one would have fought them with the efficiency I did.

    I want to stress that my post isn’t the rambling of some desperate man. I have a very well paid job, I can get the women I want rather easily, I’m not stupid and I sure doesn’t look ugly. But it’s a hassle every day to fight the side effects as new one’s appear with time.

    Yes I have clear skin and people only gave me compliment on how good I look and how strong I am, if only they knew the works it takes me to be like that.

    My brother have used the tane with great success, he tried to comit suicide because of his acne, and now he lives a great life.

    But acne can be treated differently (by avoiding dairy products and such things).

    I have to say that accutane didn’t work well on clearing my acne, it is only when I had to quit taking dairy product (due to bowel disease) that I got 100% clear. I took back ago dairy products again and acne came with a vengence, when I stopped them acne fadded.

    Roaccutane is the worst way to treat acne, they are other less harming ways. Accutane should be only reserved to those who are so desperate with their acne that they are intending to commit suicide.

    Bye

  8. wow
    it must have been a hard struggle.. damn bro
    i feel for you and im glad that atleast you got your life back on track, and i appreciate u sharing your knowledge with other
    beause no matter how scary it may seem, it is the truth
    a lot of people would rather over look all the dangers and just take accutane hoping that it will not affect them and that if it did they will deal with it when the time comes

    thats wrong, you gotta weigh the gains against the losses, is it really worth it?

    mod, you say to cut out dairy products.. is that Butter, cheese, yogurt and cream? im kinda confused as to what to eat and not to eat, i would like to give this no dairy diet a proper go.. what should i do?

  9. mod, you say to cut out dairy products.. is that Butter, cheese, yogurt and cream? im kinda confused as to what to eat and not to eat, i would like to give this no dairy diet a proper go.. what should i do?

    man, before I was so deep into that sh*t that derms say, that diet doesn’t affect at all acne. Altough I knew chocolat break me out , I never knew diet plays such an important role in acne.

    Milk is used by cows to feed their child, it is thus loaded with hormones, and no way the human body is made to handle these hormones, they are other things that cause break out due to dairies tough.

    But to see a real difference in acne, you should avoid all dairies (milk, cheese, yogurth, evrything that’s made of milk), the only thing you have to do is take a calcium pupplement to prevent deficency. Give it a try for 20-30 days and see if your acne, start improving.

    Some have problem with dairies other with sugar, but the thing I’m 100% sure now is that food plays a big role in acne. Why, because at the worst of my sickeness I was eating only a small part of bread and 100 g of meat per day, and I had the best skin ever, hell I didn’t shower for 7 days and hadn’t got any breakout, while I used to shower every day to prevent from acne even after the tane.

    bye

  10. [quote]hmmm……….maybe some people should post positive thoughts to make this a little less biased

    andy, we’re not talking about thoughts, we’re only talking about science and how roaccutane works, like I said I have been wondering if I had the right to post how roaccutane works because yes it is scary.

    Also I know that ROCHE do surf a lot of acne board on the net (for feedack), and the IP they use can be traced down to a roche.com domain. If one of the guys from roche disagree in what is in my post, I’ll be more than happy to discuss this with him. But he can’t disagree on truth :lol[/quote]
    nonononononono i didnt mean ur 1st post that was scientific, very good! i ment ur second one with all the negative messages uve been receiving. What im saying is that most people ignore the positive ones! and perhaps they should b in this too so people really do get the full story. 8)

  11. I want to agree with mod in the sense that accutane should only be taken by people with severe nodular cystic acne because of the risk of side effects. Im against accutane now cause i have seeing the pain of people like mod here and Im totally against a medication that just could even damage one life up. Accutane should be out of the market. However I also want to to say that the theory of anarchaic cell development, premature aging and modified genetic material is hypothetical. If the mechanism of action of this drug is unknown then how can we assure this can be thruth?? Im 6 months post ro accutane and have had my nerves affected believing I could have been affected by the drug because i started to have stomach problems 3 months ago. They are going away now, and eating Vit A or not does not make any difference. I have had insomnia, loss of apetite, even loss hair (when you are stressed your hair stop from reproducing) and with little to no medication everything is fading away. When I have told to my doctors about the drug and the relation it might have to my symptoms they look to me as Im crazy and assure me there is no relation. I am sure if you do have side effects during your course and they continue afterwards you can say for sure it has been the drug but that of side effects years afterwards there is no assurance it was the drug and I wouldnt like that people here have to suffer what I have suffered torturing their minds and having sickness unnecesary because its an awful experience as well.

    To mod and all that have truly suffered the devastating side effects of this drug I want to say my heart is with all of you and this site will collaborate in any way possible to prevent the use of this drug. Never loose hope and remember that there is a mighty God that can heal where doctors cannt heal. He is the creator of life and the bible says if you believe in him you will see HIs Glory. Sounds melo and its very difficult to believe when we are in deep pain but it works. The thruth, the sole thruth its written in the Bible and thats where our faith should lie and not what its written in a book by a stupid doctor. Amen!

    Mari 😀

  12. However I also want to to say that the theory of anarchaic cell development, premature aging and modified genetic material does is hypotical. If the mechanism of action of this drug is unknown then how can we assure this can be thruth??

    I may sound a bit rude but you’ll excuse it because Jan Ulrich just felt out of his bike and he sure has lost the ITT, can’t even see the end of it :cry :cry :cry :cry :cry :cry :cry )

    Well I’m very disappointed with what you are saying because I tought from what we talked about that you were agreing with me.

    It’s not hypothesis, it hasn’t been prooven 100%. you have to know how scientist works to understand the meaning of it.

    Scientist has to know the exact process (all the process) to say it it true. But all the research shows that retinoids afftects cells receptors and not only the RAR and RXR. It affect all the superfamily of nuclear receptors (steroids-thyroids-retinoids), and those recpeptors works in interrelation between them. If you act on the RAR and RXR recpetors of the cells (and this is proven, you want the study I have them) you messes with all the other nuclear receptors. (it is proven and I have the studies), so roaccutane by healing acne (and affecting RAR and RXR recpetors) affect also (VDR,ER,PR,GR…….) recpetors and these recpetors are the one that control all the body. I didn’t want to bring all the scientific stuff because I wanted to make my post as clearer as possible for everyone to understand, but if you want and I can come to it. Because retinoids has been shown to influence all these recpetors (I have the study to anyone who wants them, I need just an email adress to send)

  13. Im 6 months post ro accutane and have had my nerves affected believing I could have been affected by the drug because i started to have stomach problems 3 months ago. They are going away now, and eating Vit A or not does not make any difference. I have had insomnia, loss of apetite, even loss hair (when you are stressed your hair stop from reproducing) and with little to no medication everything is fading away. When I have told to my doctors about the drug and the relation it might have to my symptoms they look to me as Im crazy and assure me there is no relation.

    during one year I had no symptoms and tought I was totally healed and tought that the diarrheoa was in my mind, don’t bring me there because that’s were you’re gonna know what anxiety really is.

    Look I made this post for several reason, one of thel is that I saw a month ago the derm that gave the stuff to me, and she was the first doctor that listened to me without thinking she is some kind of superior because she has a medical degree. And she totally agreed on my demonstartion, altough at first she was really scpetical. She invited me after her work hours because she was more than intrigued from what I told her. I never posted this because I always tought taht peopel were to stupid to listen, but if even a derm can listen, well everyone can.

  14. Never loose hope and remember that there is a mighty God that can heal where doctors cannt heal. He is the creator of life and the bible says if you believe in him you will see HIs Glory. Sounds melo and its very difficult to believe when we are in deep pain but it works. The thruth, the sole thruth its written in the Bible and thats where our faith should lie and not what its written in a book by a stupid doctor. Amen!

    Mari 😀

    We are talking science here, science and religion don’t mix well.

    it has nothing to do with me being in pain, I believed in god way before suffering from the tane, and I have no lessons to take from anyone when it comes to god and religion.

  15. Marilia I have to say that I am more than disappointed from what you’ve said, I tought that at least you weren’t from those that are so quick in negating people pain.

    I guess now that you feeling better you forget absolutely everything about what you said to me about the tane. Well I will put this on the human nature who always forget the pain they’ve been through. 😕

    bye

  16. If the mechanism of action of this drug is unknown then how can we assure this can be thruth?? Mari 😀

    who told you it is unknown.WHO????????????????????????????????????

    they are known.

    It’s true.

    You want studies, I got them, ask me to send them i’ll send them. here’s a little site of some

    There are two classes of RA (retinoic acid) receptors: RXRs (retinoid-X-receptors) and RARs (retinoic acid receptors) (Lu et al., 1997). Both receptors are ligand-dependant transcription factors that belong to the nuclear hormone receptor superfamily. RXRs can form heterodimers with RARs and with other nuclear receptors, including those for thyroid hormone and vitamin D (Lu et al., 1997). In these heterodimers, RARs are activated by all-trans RA (atRA) and 9-cis RA (9cRA), whereas RXRs are activated only by 9cRA (Lu et al., 1997).

    Retinoic acid was first proposed to be involved in neural development when it was shown that exogenously-applied retinoic acid produces a concentration-dependant truncation of anterior regions and enhancement of posterior structures in Xenopus embryos (through its influence on the embryonic mesoderm and ectoderm) (Blumberg et al., 1997). It was also shown that retinoic acid could mimic the action of endogenous signals involved in inducing posterior gene expression in the Xenopus nervous system. Because both of these experiments were based on gain of function, using exogenously-applied RA on in vitro explants, its role in development and evidence for its involvement in normal processes remains debatable. To overcome this problem, experiments were done using both dominant-negative RA receptors and constitutively-active RA receptors, an approach that allowed investigation in vivo, using intact embryos.

    Studies may not be on accutane, but are on retinoids (and accutane is a retinoid).

    I assume you should go to the RAG forum and ask andrew what he has to say on what I wrote (I made the same post on the RAG) He agree 100% with what’s written and he has a high degree in chemistry and biology.

    I am sorry marilia to say it like this but we ain’t moving in the same waters here. You don’t have the level required to understand the mechanism by wich accutane works, so the discussion will go nowhere.

  17. As for the symptoms occuring years after the tane is stopped ::

    By – Laurel D. Prokop, ELS, MT (ASCP)
    Principal Consultant – Techstyle Information Services

    People who are treated for acne with the pharmaceutical drug ACCUTANE risk developing one of two serious gastrointestinal diseases identified together as “inflammatory bowel disease”, or IBD. These are Crohn’s disease and ulcerative colitis, or UC. Patients with Crohn’s or UC require lifelong medication and often need surgery, including partial or total removal of the intestine and colon.

    The warning symptoms a patient may experience–either while on Accutane or even months to years afterward–include abdominal bloating and gurgling; frequent, loose, or bloody stools; and abdominal pain. The drug’s maker, Roche Pharmaceutical, acknowledges what it calls Accutane’s “temporal association” with IBD. This means that IBD has been seen to develop in patients while taking or after taking the medicine, but that no study has proven cause and effect. Unfortunately, many doctors misunderstand “temporal” as “temporary” and presume that these symptoms are expected and unimportant and will go away when Accutane treatment is stopped. Also, some patients wait a long time to see a doctor, and many patients are even misdiagnosed with “irritable bowel syndrome” or another less-serious disorder, and told just to experiment with diet or reduce stress. In fact, many doctors do not know how to file reports with the FDA. Therefore, adverse-reaction reports are rarely filed. Because of this, Accutane’s disease-causing side effect has not been publicized, and the FDA has not issued a warning.

    If you are on Accutane or have taken it and experience any of the symptoms mentioned, see a gastroenterologist immediately, ask the doctor to consult Roche’s warnings about Accutane, and—most importantly—to test and treat you if necessary. If you are diagnosed with IBD, make sure a report is submitted to the FDA and to Roche. Contact the sources listed below.

    For copies of MedWatch Adverse Reaction Form and Instructions, contact the FDA via phone or internet:

    MedWatch @ 1-800-FDA-1088 (1-800-332-1088) or http://www.fda.gov/medwatch/how.htm

    Roche Pharmaceuticals adverse reaction hotline: 1-800-526-6367 or http://www.roche.com

    Yet again it’s nit because it hasn’t been proven yet at 100% that it is false.

    When pierre and marie curie started experinecning with radioactive material they didn’t know that it was cancerigen, and even after people developped cancer from radioactivity, people were told it HASN’T BEEN PROOVEN that radioactivity causes cancer.

  18. I. When I have told to my doctors about the drug and the relation it might have to my symptoms they look to me as Im crazy and assure me there is no relation. Mari 😀

    ask them what the difference is between 11 cis retinal and tout trans retinal, what recpetors does isotretinoin activate, what’s it’s molecular weight, what’s it’s pharmaco cinétique, what’s the half life it and other retinoids (such as etretinate), ask them how long etretinate stays in the plasma…..

    What are they gonna answer????. they are gonna say : we don’t know. So basically they don’t know anything about accutane and retinoids and yet they can affirm that there is no relation between the drug and your symptoms. :roll :roll

  19. [quote][quote]hmmm……….maybe some people should post positive thoughts to make this a little less biased

    andy, we’re not talking about thoughts, we’re only talking about science and how roaccutane works, like I said I have been wondering if I had the right to post how roaccutane works because yes it is scary.

    Also I know that ROCHE do surf a lot of acne board on the net (for feedack), and the IP they use can be traced down to a roche.com domain. If one of the guys from roche disagree in what is in my post, I’ll be more than happy to discuss this with him. But he can’t disagree on truth :lol[/quote]
    nonononononono i didnt mean ur 1st post that was scientific, very good! i ment ur second one with all the negative messages uve been receiving. What im saying is that most people ignore the positive ones! and perhaps they should b in this too so people really do get the full story. 8)[/quote]

    yes you are right, but look at these two posts (made by the same person but month apart)

    at first pro accutaner

    http://www.clearskin4me.com/viewtopic.php?t=1180&highlight=roche+nurse

    saying that what people say about the bad side effects of the tane is BS

    then after experiencing them

    http://www.clearskin4me.com/viewtopic.php?t=1654&highlight=accutane

    PS : sorry shaunabns1 to brought you to this but I had to make a point. hope you understand 🙂

  20. should we take it?

    1 in 500,000 ppl have pro-longed side effects, the rest end up with beautiful clear skin and no problems

    i know what i would be doing if i was suffering from acne

  21. should we take it?

    1 in 500,000 ppl have pro-longed side effects, the rest end up with beautiful clear skin and no problems

    i know what i would be doing if i was suffering from acne

    1 out of 500 000, man I hope you are jocking. lets say 1 of 10 000 at least, (damn I had those stats but I lost them due to fromat c:/q). and yet I’m pretty sure it’s more than than. Didn’t you read to messages I posted. I received way more than that, and I’m not a doctor or something, I’m not a publically known person and yet a received at least 20 person having long term side effects, and don’t talk about the others that don’t have the net, or don’t even know that the disease they developped years after is from the tane.

  22. 20s still not that many if u think about how many people there r! i mean no ones going to pm u with positive stuff r they really its only the sufferers who come together and talk about it.

  23. 20s still not that many if u think about how many people there r! i mean no ones going to pm u with positive stuff r they really its only the sufferers who come together and talk about it.

    you have to understand that accutane isn’t my life, like I said I’m not a guru for roaccutane or something, people can’t email me like that, they have to find me for that, and I’m more on my favorite french bodybuilding board than on acne boards.

    As for the 20 I just threw taht number,

    last 2 days here’s the oneS I had :

    Hi-

    I was wondering if you kne how I could get information about the Richard Evans treatment (IE how to contact him, etc.)

    Please email me at *********.org if you can help.

    thanks,

    Hiya can u tell me more as to why the aching muscles are a serious side effect?? i have read a few posts with this problem.

    the richard evans treatment is supposed to cure the bad side effects, as for the other guys he’s suffering from constant mucle pain.

    Like I said I am one person and yet more than 20 others have emailed/Pmed me, and I’m not a very active member on the RAG. and a lot of people developped diseases years after the tane but they are unable to make a relationship because it’s not known that accutane can cause side effects years after cessation of therapy.

    One last think, the tane didn’t clear me, it’s because I was so sick that I had to give up dairy products that I’m clear now.

    48% of people that took the tane, will take it again because acne has came back. Accutane stinks and as long as this drug is on the market, no company will invest money on research and devellopement because roaccutane is a big concurrence, roche are selling this nasty drug to desperate people, knowing that it’s a heavy drug. If accutane is banned I don’t give it 5 years before they come with a more effective and less stressfull treatment to fight acne. The acne drug market is a big one but accutane is preventing other companies from investing in research and develoopement.

    AND QUITE FRANLY I FUCKING DON’T CARE, PEOPLE HAVE THE RIGHT TO DO WHAT THEY WANT.

  24. Marilia I have to say that I am more than disappointed from what you’ve said, I tought that at least you weren’t from those that are so quick in negating people pain.

    I guess now that you feeling better you forget absolutely everything about what you said to me about the tane. Well I will put this on the human nature who always forget the pain they’ve been through. 😕

    bye

    Mod,

    I have stated before I am NOT a proaccutaner anymore and I want to help. I have not forget anything and I think is an offense to you say that I negate people’s pain. If that were the case I wouldnt have build up this site in the first place. My heart deeply aches for all those who suffer specially those dragged down by the devasting side effects of accutane. I pray for all of us continuosly.

    What i was just stating is that we cann’t assume that all health issues that may arise after an accutane treatment necesseraly have to do with accutane and that not all induviduals are affected by taking this medication. However considering the individuals that are susceptible to this medication accutane should be banned because what if any of us is or what if one of our sons is. I had suffered from the stomach, im recovering now but I dont forget the pain I had. But as much as it hurts and as I much I want to say it came from the ‘tane I cannt assure it was from the accutane. It could have been coincidence. And this is what doctors told me.

    Mod digging on books looking how accutane the trans or cis form will affect your body will sunk your brain down, it will take control of the mind part where you dont have control, the one that does the things we cannt explain. Your body goes where your mind goes. If I keep reading on disaster I will end up sick and die. You say me accutane mechanism of action is proven then lets show it to fda, they cannt be blind about it. Thats the agency that control rdrugs and I know for a fact they act because I saw closely in PR the case of Warner Lambert where the chemists called fda and next day fda was there and I know of the people who suicided before they got into jail, retired medications from the market and such. If there is proof no matter this comapny makes millions they will act. Lets pile up those documents and send to fda. Also if the mechanism is proven then there is chance to discover what could work to counteract it. Let the doctors rest and lets use all those biochemical knowledge you have to discover a cure. I see that mathew hamilton and richard evans are close to discover something they should share so more could join in the search, like symposium and do something for this planet. But you see they dont want to share information. Why is that??????? That is what I can call ignoring people’s pain. And Im sure if Evans is truly concnerned about accutane sufferers that info can be send anonymous if what he is scared is to have bullets in his mouth. Its very sad.

    If there is any form me and this site could contribute to the accutane cause let me know as Im here to help and I will always hear ‘ya. I’m trying to do my best here.

    -Mari

  25. Mod,

    I have stated before I am NOT a proaccutaner anymore and I want to help. I have not forget anything and I think is an offense to you say that I negate people’s pain. If that were the case I wouldnt have build up this site in the first place. My heart deeply aches for all those who suffer specially those dragged down by the devasting side effects of accutane. I pray for all of us continuosly.

    What i was just stating is that we cann’t assume that all health issues that may arise after an accutane treatment necesseraly have to do with accutane and that not all induviduals are affected by taking this medication. However considering the individuals that are susceptible to this medication accutane should be banned because what if any of us is or what if one of our sons is. I had suffered from the stomach, im recovering now but I dont forget the pain I had. But as much as it hurts and as I much I want to say it came from the ‘tane I cannt assure it was from the accutane. It could have been coincidence. And this is what doctors told me.

    Mod digging on books looking how accutane the trans or cis form will affect your body will sunk your brain down, it will take control of the mind part where you dont have control, the one that does the things we cannt explain. Your body goes where your mind goes. If I keep reading on disaster I will end up sick and die. You say me accutane mechanism of action is proven then lets show it to fda, they cannt be blind about it. Thats the agency that control rdrugs and I know for a fact they act because I saw closely in PR the case of Warner Lambert where the chemists called fda and next day fda was there and I know of the people who suicided before they got into jail, retired medications from the market and such. If there is proof no matter this comapny makes millions they will act. Lets pile up those documents and send to fda. Also if the mechanism is proven then there is chance to discover what could work to counteract it. Let the doctors rest and lets use all those biochemical knowledge you have to discover a cure. I see that mathew hamilton and richard evans are close to discover something they should share so more could join in the search, like symposium and do something for this planet. But you see they dont want to share information. Why is that??????? That is what I can call ignoring people’s pain. And Im sure if Evans is truly concnerned about accutane sufferers that info can be send anonymous if what he is scared is to have bullets in his mouth. Its very sad.

    If there is any form me and this site could contribute to the accutane cause let me know as Im here to help and I will always hear ‘ya. I’m trying to do my best here.

    -Mari

    Thing is taht when a guy whith a banal chron disease like s-LO can’t be cured by any chron medication you sure is the tane, because S-LO doesn’t have a “usual” chron.

    Same as some people (like me) that are suffering from IBS that get worst even with the diet.

    FDA, they can go to hell, money rulez them, you can shut them with money. And as I stated earlier I sure don’t have neither the time nor the willingness to put effort in this while ignorant people still disagree with me while they don’t know a f*ck about the tane. This is certainly not my war and will never be. I don’t think Helping people is that rewarding (knowing all the selfishness that is in the world).

    Also for future discussion don’t bring your case (stomach pain)in the subject, you say you are subject to anxiety so no need to add more to it.

    About the richard evans treatment, I am keeping my mouth shout for now, due to the respect I have for the people that paid 20 000 * for a so called cure. The post is already in my mind (with all the argumentation) and as soon as I will find it necessary I’ll break this chimera down to pieces.

    and as for the books about retinoids, well I told you I’m between two jobs for 2 months so I have time on hands and I’m just reading what I like, that’s not the only stuff I’m in to right now. Looking for roids, dietetic books…… I don’t really watch TV, and I’ll only start to go out again when I’m back in france which is only a matter of time.

  26. To Mod
    Firstly excellent post the only time I have seen what genes accutance affects.Its about time after 20 years this drug was shown up for what it truly is.
    Congratulations in your efforts to expose and inform.
    However 3 objectives must be met in terms of this drug
    1- To ban it
    2- To create some kind of treatment/program thats gonna reverse effects for people who have already taken it
    3- Create something effective in treating acne that is safe

    Mod- With regards to Richard Evans you say take this Chimera to pieces, does this mean a scam or what does Chimera mean ?

    thankx

  27. should we take it?

    1 in 500,000 ppl have pro-longed side effects, the rest end up with beautiful clear skin and no problems

    i know what i would be doing if i was suffering from acne

    YOU SAY YOU DON’T SUFFER FROM ACNE, YET YOU ARE ON A ACNE BOARD.

    YOU REGISTERED ON THE BOARD ONE DAY AFTER I MADE MY POST, YOU TOOK GUEST AS A NICK, AND YOU TAKE THE PRECAUTION TO CHECK THE NO EMAIL SHOWING OPTION (SO WE DON’T KNOW WHAT’S YOUR EMAIL) THEN YOUR FIRST POST (AND ONLY ONE ) WAS ANSWERING MINE A DAY AFTER YOUR REGISTRATION, TRYING WITH WAY UNDERATED SIDE EFFECTS RATIOS (1/(500 000) TO MAKE MY POST LOOK BOGUS.

    YOU DIDN’T POST ANY OTHER MESSAGE SHOWING THAT YOUR REGISTRATION WAS ONLY MADE TO ANSWER MY POST AND MAKE IT LOOK BOGUS. IF I HAD ADMINISTARTION RIGHTS I WOULD DEFENETLY MAKE AN IP AND DOMAIN NAME CHECK JUST TO MAKE SURE IT DOESN’T SHOW A ROCHE.COM ONE.

    CAN YOU SAY ROCHE PIMP???

    OK ENOUGH WITH PARANOIA :shock

  28. To Mod
    Firstly excellent post the only time I have seen what genes accutance affects.Its about time after 20 years this drug was shown up for what it truly is.
    Congratulations in your efforts to expose and inform.
    However 3 objectives must be met in terms of this drug
    1- To ban it
    2- To create some kind of treatment/program thats gonna reverse effects for people who have already taken it
    3- Create something effective in treating acne that is safe

    Mod- With regards to Richard Evans you say take this Chimera to pieces, does this mean a scam or what does Chimera mean ?

    thankx

    First of all thanks for the nice words, it’s always good to hear that a post you take time to write did reach others people mind.

    as for richard treatment it’s not a scam, but I have talked with him for more than half an hour and the things he told me aren’t true. there is a lot of errors in his argumentation. Like I said people that took the treatment are reading this board and I don’t really want to make any kind of comment right now. I am yet not 100% about my opinion on this treatment, but I would defenetly not recommand to anyone to take it. richard has a deadline because he said that in months people will be cured after they took the treatment. I think people will not be cured (I can be wrong) but when I will be 100% sure that I’m not I will post and explain why richard evans treatment doesn’t work.

    May god make me wrong, as I know this treatment is a last hope for a lot of people.

  29. This may be a stupid question(you don’t have to agree on that), but are there safer ways of using accutane mod? I remember reading a post before I started my accutane, where-in the author wrote that he was going to take the accutane until his skin cleared and then go on a monthly maintenance dose of one accutane pill for the rest of his life. I’m on my sixth week of accutane and I’m intrigued by this method. But do you think in the long-run that the side effects would still be a problem even with such a small dosage of this drug? Since you are an accutane genius, your input is very important to me 🙂

  30. Oh, and my skin is clear. That’s why I’m looking into this new method of one pill of accutane a month.

  31. This may be a stupid question(you don’t have to agree on that), but are there safer ways of using accutane mod? I remember reading a post before I started my accutane, where-in the author wrote that he was going to take the accutane until his skin cleared and then go on a monthly maintenance dose of one accutane pill for the rest of his life. I’m on my sixth week of accutane and I’m intrigued by this method. But do you think in the long-run that the side effects would still be a problem even with such a small dosage of this drug? Since you are an accutane genius, your input is very important to me 🙂

    Firstly I’m not an accutane genious, I am merely a person that educated himself on this drug.

    What is unknow in the tane, is what dosage is dangerous for every individual, what is the best length of course (clear VS dangerosity), I know that some take accutane to make wrinkles fade at low dosage during at least 18 month. taking accutane at low dose long terme has been shown to have devasting effect on the human body. I was personnally contact by a guy who did it and was still doing it while experiencing bad side effects. Was he jocking or not, I don’t know.

    Like alicya said, even at very low dose accutane shouldn’t be taken to prevent reapparition of acne after a treatment.

    bye

  32. wHAT ARE U LAUGHING AT ?
    Some ppl are misinformed, therefore need educating not laughing at…

  33. Should we take it?

    99.9% of accutane users thank god for the drug and go on to lead happy acne-free lives..

    i know what i would be doing if i suffered with acne, why live in fear, live in hope.

  34. Should we take it?

    99.9% of accutane users thank god for the drug and go on to lead happy acne-free lives..

    i know what i would be doing if i suffered with acne, why live in fear, live in hope.

    only 60% of users have clear skin after an accutane course, yet again you’re here with your false claims, you roche PIMP.

  35. After reading the Roche website and some of their product info lists it seems Accutane isn`t the only risky drug they manufacture, actually it seems to be a trait of the companY. They seem to have a penchant of creating drugs in which PSYCHIATRIC AND TERATOGENIC SIDE EFFECTS ARE possible.
    EXAMPLES- LARIAM
    PEGASYS
    SORIATANE
    VESANOID

    There are more i just could`nt be bothered to read thru them.
    Or perhaps Roche just make drugs that are required in life-saving situations therefore side effects are big ?

  36. we should take it

    1 in 500,000 ppl have pro-longed side effects, the rest end up with beautiful clear skin and no problems

    i know what i would be doing if i was suffering from acne

    I agree. People should not be scared of taking the drug, the incidences of severe side effects are totally rare. Don’t listen to these two internet hacks, talk to your DOCTORS. This is supposed to be a support forum I thought…

  37. To Mod

    1- To ban it
    2- To create some kind of treatment/program thats gonna reverse effects for people who have already taken it
    3- Create something effective in treating acne that is safe

    Mod- With regards to Richard Evans you say take this Chimera to pieces, does this mean a scam or what does Chimera mean ?

    thankx

    I don’t understand why people are getting so upset. The drug does not cause enough severe side effects to even come CLOSE to being banned (check your countries relevant pharm. reg. board) And that is the pure and simple fact. No one is denying some unfortunate people do get them, but they are well within the acceptable incident rate of pharms… I agree with point (3) above – Scientists are always working on ways to improve drugs as we all known. It is always difficult as the body is complex, trying to correct one problem always ends up causing another, the question is finding a balance, perhaps in the future a more even one.

  38. [quote]To Mod

    1- To ban it
    2- To create some kind of treatment/program thats gonna reverse effects for people who have already taken it
    3- Create something effective in treating acne that is safe

    Mod- With regards to Richard Evans you say take this Chimera to pieces, does this mean a scam or what does Chimera mean ?

    thankx

    I don’t understand why people are getting so upset. The drug does not cause enough severe side effects to even come CLOSE to being banned (check your countries relevant pharm. reg. board) And that is the pure and simple fact. No one is denying some unfortunate people do get them, but they are well within the acceptable incident rate of pharms… I agree with point (3) above – Scientists are always working on ways to improve drugs as we all known. It is always difficult as the body is complex, trying to correct one problem always ends up causing another, the question is finding a balance, perhaps in the future a more even one.[/quote]

    Accutane is one of the top three drugs for the most reported adverse side effects on the FDA’s database. The FDA estimates that only one in one hundred side effects ever get reported to the FDA.Accutane is prescribed for the treatment of severe, disfiguring cystic acne that has not resolved in response to milder medications such as antibiotics. It works on the oil glands within the skin, shrinking them and diminishing their output.

    Accutane is taken by mouth everyday for several months and then stopped. The antiacne effect produced by Accutane can last even after finishing a course of medication. Accutane, generically known as Isotretinoin, is a synthetic derivative of Vitamin A.

    The side effects caused by this drug can be horrific. Accutane gained notoriety in the mid to late eighties for the severe birth defects caused by the drug. In addition to birth defects, the drug is associated with causing severe psychiatric side effects as well as many systemic side effects including damage to the liver, kidneys, central nervous system, pancreas, gastrointestinal tract, cardiovascular system, musculosketal system, and the auto-immune system of the human body.

    Many side effects are permanent, severe and devastating to an individual. The fact that so many people are experiencing adverse effects from this drug is not surprising.
    In 1998, the Food and Drug Administration advised doctors who prescribe Accutane to monitor their patients for signs of depression. Subsequently, the manufacturers of Accutane, Hoffman-LaRoche, notified doctors that the drug “may cause depression, psychosis, and, rarely, suicidal ideation, suicide attempts and suicide.”

    However, the knowledge of the potential danger associated with Accutane did not become widely known until a Congressman’s son committed suicide. Rep. Bart Stupak stated that his 17-year-old son’s suicide may be linked to the popular acne medicine. Bart Stupak, Jr., also known as “BJ”, shot himself in the head with his father’s gun. Stupak, who was a football player and a popular student, killed himself after a prom-night party.

    In assessing how many potential suicide cases linked to Accutane, Rep. Stupak stated, “We are up over 100 reports, that’s just what is coming in to us, so I believe there are probably over a thousand cases.” Stupak also stated that, “the average time is 88 days from when you start taking it, and the effect is very sudden…. You are doing strange things at 3:00 a.m. and you are dead at 7:00 a.m.”

    The FDA has received reports of 66 suicides and 1,373 cases of psychiatric problems among Accutane users as of early December 2000, according to a report in USA Today. Accutane’s package warning first addressed the potential relationship between Accutane and depression in 1986.

    Although French officials required that Hoff-LaRoche add the risk of suicide to the package insert of the European version of Accutane in March 1997, the FDA did not require such a change in the USA until 1999. As recently as November 2002, Roche Laboratories distributed a “Dear Doctor” letter to physicians regarding severe adverse events — this time concerning a greater risk of bone fractures during therapy with their medication.

    In September 2000, Hoffmann-LaRoche reported to the FDA advisory committee that since Accutane’s approval in September 1982, five million people in the United State and twelve million people worldwide have taken the drug. The majority of these people are teens and young adults. Accutane, an oral medication, was approved by the Food and Drug Administration for the treatment of recalcitrant cystic nodular acne. However, through clever marketing to health care providers and through generic advertising in media outlets such as Nickelodeon, an estimated 90% of all Accutane prescriptions are given for “off-label” uses.

    Accutane is one of Hoffmann-La Roche’s top three drugs, having sales of approximately 1.2 billion dollars annually. We obtained testimony, given by Roche’s representatives in the early 1980’s, indicative that the manufacturer expected 100% of all patients taking the drug to experience side effects. Unfortunately, Hoffmann-LaRoche marginalized the more severe side effects of Accutane and focused on minor conditions such as dry skin.

    Hoffmann-LaRoche is part of “The Roche Group”, a leading international health care company principally rooted in the businesses of pharmaceuticals, diagnostics and vitamins. The Roche Group is made up of numerous subsidiaries and is active in more than 150 countries. They are the seventh largest pharmaceutical company in the world. Our research on the manufacturer of Accutane is extensive.

    The Roche Group is well known throughout the legal system with regards to both civil and criminal activity. They have been found guilty of fraudulent conduct, discovery abuses, and patent infringement, including committing fraud against the United States Trademark and Patent Office. In 1999, Roche budgeted over one billion dollars for criminal fines, penalties, and settlement of cases. Their corporate executives have been sentenced to prison for their activities.
    Because of Accutane, Hoffmann-LaRoche is currently the subject of a Congressional investigation. The Subcommittee on Oversight and Investigations of the House of Representatives Energy and Commerce Committee reconvened its investigation into Hoffmann-LaRoche and Accutane in early December of last year. One of the members of that Committee, Congressman Bart Stupak, stated the following during the Congressional Investigation:The drug manufacture, Hoffmann-LaRoche, Roche here in the United States, has continued to put profits before people. They have done everything possible to prevent the American people from learning of the psychiatric injuries and deaths associated with Accutane. Even, today, I’m sure Roche will still deny any casual effect of Accutane with the abortions, deaths, and suicides caused by their product.
    The President and Chief Executive Office of Hoffmann-LaRoche, Inc. (USA), George B. Abercrombie, also testified before the Committee. After giving various statements and making representations under oath regarding studies, marketing, clinical trials, and Roche’s relationship with entities in Mexico, Mr. Abercrombie was told by two members of the Committee that his testimony was not credible and was given in front of the Committee with a “straight face”. Significantly, not a single member of the Committee spoke in support of Hoffmann-LaRoche. This investigation is presently ongoing.

    The FDA has restricted the writing of prescriptions for Accutane. They must be written on a valid prescription (telephone, fax, and computer-generated prescriptions are not valid); they must have a yellow sticker with a registration number on it; patient education booklets must be dispensed with every filling; they may not be written for more than a one-month supply; and they must be filled within 7 seven days of being written.

    Even though this drug is classified as a C-5 (no more harmful than other, non-controlled, prescription drugs), the restrictions placed upon its prescribing and dispensing are usually reserved for more dangerous agents such as narcotics. In fact, the only other drug with similar restrictions is Thalomid, a drug used to treat many serious conditions, most commonly cancer.

    With the evidence of adverse reactions that continues to mount with its use, it is more apparent than ever that Accutane is a drug with risks that may far outweigh its benefit. While the true incidence of side effects remains unknown due to underreporting and downplaying, the side effects we are aware of are enough to warrant serious caution when dealing with Accutane.


    DERMS DO NOT REPORTS ADVERSE SIDE EFFECTS, THE FDA STATES THAN MORE THAN 99% OF SIDE EFFECTS ARE NOT REPORTED, DERMS DO NOT KNOW THAT ACCUTANE CAN CAUSE DAMAGE YEARS AFTER. WHEN YOU’RE SICK FROM THE TANE AND WHEN YOU GO TO A DOCTOR HE JUST SAY NO IT’S NOT THE TANE. SO HOW WOULD YOU WANT HIM TO REPORTE IT.

    WHEN NUCLEAR WEAPONS WHERE TESTED NO P¨RECAUTIONS WHERE TAKEN FOR THE SOLDIER, IT TOOK MORE THAN 50 YEARS FOR THEM TO TAKE SOME KIND OF COMPENSATION, SOME ARE DEAD AND SOME ARE STILL WAITING.

    I’M DONE WARNING AGAINST ACCUTANE, i SINCERELY HAVE DONE MY JOB ( AT LEAST I THINK I’VE DONE IT) TAKE THE SHIT AT YOUR OWN RISK.

    Bye, it’s your own body after all.

  39. [quote]we should take it

    1 in 500,000 ppl have pro-longed side effects, the rest end up with beautiful clear skin and no problems

    i know what i would be doing if i was suffering from acne

    I agree. People should not be scared of taking the drug, the incidences of severe side effects are totally rare. Don’t listen to these two internet hacks, talk to your DOCTORS. This is supposed to be a support forum I thought…[/quote]

    Man I didn’t see this post before I answered the later.

    All I have to say is that your mom was sure listening to me when I f*cked her yesterday.

    So give a bit of respect to the father of your next little brother.

  40. [quote]we should take it

    1 in 500,000 ppl have pro-longed side effects, the rest end up with beautiful clear skin and no problems

    i know what i would be doing if i was suffering from acne

    I agree. People should not be scared of taking the drug, the incidences of severe side effects are totally rare. Don’t listen to these two internet hacks, talk to your DOCTORS. This is supposed to be a support forum I thought…[/quote]
    I received more than 10 email from the US from the people that complain from permanent side effects. 5 millions have took the tane in the US.

    500 000 * 10 = 5 millions,

    so basically with your bogus ratios your saying that I received email from ALL the people who suffered from the tane. Me alone I received all the people that are suffering from perm side effects.

    I didn’t want to bring it, but If I rmemebr well one person on 1000 who took the tane suffer from inflammatory bowel disease. A large part of them will suffer from it for life. I’m not talking about the other side effects as I just can’t find that study.

  41. Accutane is the best thing to ever happen to me. I think it is a miracle drug. I have been on it 16 weeks and my skin is clear. Nothing else ever worked for me and I’m not someone willing to try a strict diet to get rid of acne. I still have to see what happens when I go off in 2 months, but I know that right now I am clear and that I wouldn’t be without accutane and I am grateful for that.

  42. Accutane is the best thing to ever happen to me. I think it is a miracle drug. I have been on it 16 weeks and my skin is clear. Nothing else ever worked for me and I’m not someone willing to try a strict diet to get rid of acne. I still have to see what happens when I go off in 2 months, but I know that right now I am clear and that I wouldn’t be without accutane and I am grateful for that.

    it’s so funny to see that 2 posts member that only registered the same day are posting the positive comments on the tane. And all the tane, it’s just an opinion on the safety of roaccutane, no facts or proof that accutane is safe.

  43. I only registered because the board no longer lets me post without being registered. I have posted on here before. I believe accutane is a miracle drug and I know others who cleared on it as well. Obviously there are risks, but that is why your blood is monitored. I will never regret taking accutane, I wish I had taken it sooner.

  44. I only registered because the board no longer lets me post without being registered. I have posted on here before. I believe accutane is a miracle drug and I know others who cleared on it as well. Obviously there are risks, but that is why your blood is monitored. I will never regret taking accutane, I wish I had taken it sooner.

    I more than happy for you that it cleared you. Blood monitoring doesn’t show everyhting (especially when it comes to the permanenet severe side effects), there are no way how blood monitoring will show an chemical imbalnce in the brain, the starting of a bowel disease, a muscle inflammation.

    I’m more than happy that it worked for you but don’t talk on a drug that you know nothing about as a “miracle” drug. Besides I always say that one should at least wait till some months after the course before saying saying that he/she is clear. Hope it will be the case for you.

    Like I said on this post the only argumentation I’ll accept is a scientific one, I have yet to find someone that come with it, if you are so happy from the tane why don’t you start your own thread based of no scientific support on how accutane is the panacea of all drugs.

    bye.

  45. mod;i thought you were a really nice,helpful person when you were PMing me and helping me with my questions;but i have to say i don’t agree with the way you are answering back to people in this thread.By all means give us your information and tell us your opinions about roaccutane but please don’t call people the way you are and i’d rather you didn’t call people the awful names you are using.After all,they are only giving their point of view too.

  46. I’m really frightened now bc I just started taking isotretinoin. 🙁 I’m definitely going to mention your research to my derm (and give credit where it is due, of course) at my next appointment and also find out if any of his other patients had problems with it. Thanks for the heads up.

  47. Ringo print out the post and show it to your derm and let us know.

    Okay sorry i havent readed this thread latetly, had to edit a few posts. I want to recall this forums are for support and not to call people idiots. That is not nice. I do must want to address on mod’s comment on the risk there is with taking the drug. I aknowledge the pain with accutane sufferers of permanent side effects. I have had health issues myself Im unsure if they came from the past accutane I took but let me tell that it has scared the living shit out of me. Its true that side effects dont happen to everybody but they do happen to some and it is horrific. What if you are in this group? I can only think of people with a chron’s disease to imagine the pain. Cramping, needing a bathroom, uncontrollabe diarreah and doctor telling you you will never be cured and that you have to learn to live with it. Let me just say when you are close to this reality i can assure you if you never prayed to jesus lord you will do by then! I can only sit here and cry for all those who have to live with this reality of human pain because trying to make out a life out with a chronic disease is very hard and most when you could aknowledge it could have been prevented for just not taking the acne drug.

    I would like to call for a minute of silence there if you read me for these people that are today suffering permanent side effects due to roaccutane.

    May the lord give strength to this people and heal them..

    Okay guys hope if this thread continues it may be a peaceful one. Accutane indeed is a drug intended for severe nodulocystic acne only. As much as we wished it was good for milder acne this unfortunatly is not the case :puppydogeyes

  48. mod;i thought you were a really nice,helpful person when you were PMing me and helping me with my questions;but i have to say i don’t agree with the way you are answering back to people in this thread.By all means give us your information and tell us your opinions about roaccutane but please don’t call people the way you are and i’d rather you didn’t call people the awful names you are using.After all,they are only giving their point of view too.

    don’t even know why i’m defending myself on the net 😕

    I didn’t start the name calling until jake started it by calling me internet hack (as I say to people get me started at your own risk), you can name call me but don’t expect to get an answer from me like : why did you say that to me it wasn’t nice, jake insulted me, I insulted him back,

    as for guest his ratios are false claims, he isn’t mistaken he is making FALSE CLAIMS, when you want a person like that to shut up, you don’t tell him nicely, you just tell him SHUT UP.

    but yes I was a bit vehement towards mari but I have to say that I felt betrayed from her answer to my post (while she was , I think, agreeing with me on AIM) I felt hurt so I have reacted harsh to her you’re right.

    As for tvgirl, I don’t think I was disrespectful, I was just anoyed by her just coming with no FACT and negating my post, I stated that this post was about scientific facts at the begginning and not experience (which is not scientific)

    I’m sorry if I have offended people with my posts.

    As for jake and guest I have no regret for the insults I throwed at you. you shouldn’t have got me started.

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