More B5 Info

B5 & Acne: Frequently Asked Questions
(FAQ version 1.1)

What is B5?
How does B5 clear acne?
Is B5 safe?
Are there any side effects?
How much B5 should I take?
When and how should I take B5?
How long will it take for B5 to clear my acne?
Why can’t I get enough B5 from food?
Isn’t Coenzyme-A inexhaustible (so why should I need more B5)?
Does diet matter when taking B5?
Will B5 decrease the size of my pores?
Can I take B5 during pregnancy?
How well does B5 really work?
What if B5 doesn’t work for me?
Who discovered B5’s effects on acne?


1. What is B5?

B5, also known as pantothenic acid, is one of the “B” vitamins, and chemically is considered to be an extended amino acid. It’s biologically active form is D-pantothenic acid (dextro-rotatory isomer), though in nature the “D” form and the non-vitamin “L” form are usually found together.

B5 is a water-soluble vitamin, and is involved in a number of essential metabolic functions in the human body: it is an essential constituent of coenzyme-A (CoA), and is necessary in the metabolism of fats, carbohydrates, and protein in energy production (it is involved in the synthesis and degradation of fatty acids, and in the citric acid cycle); CoA is also responsible for the creation and regulation of hormones, and it plays important roles in the formation of antibodies and — through acetylcholine — neural function.

“Pantothenic acid” is derived from the Greek word pantos meaning “everywhere”. This name reflects the vitamin’s widespread occurrence in all living cells, being widely distributed in yeasts, molds, bacteria, and individual cells of all animals and plants.

For more information on B5, its chemical structure, functions, etc, go here¹.

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2. How does B5 clear acne?

In a nutshell (perhaps more than a bit oversimplified here), the working theory of B5’s anti-acne effect is that acne vulgaris (“vulgaris” from the Latin word for “common”) is really a symptom of a B5 deficiency in the body. Normally, B5 is used in the body to create and regulate hormones, process lipids (fats), etc. But when the body’s B5 pool is depleted, B5 (as coenzyme-A) is allocated according to the body’s own survival priorities. In other words, hormones and neural function are given as much available B5 as possible, with the process of fat metabolism receiving whatever B5 is left over from the more important processes. How does this relate to acne? Well, when they’re not burned for fuel or stored for future use, extra fats are excreted, among other methods, through the skin as a fat-rich oil called “sebum”. The skin normally has a certain amount of oil released through the sebaceous glands as a means of lubrication. But when there are excess lipids to be eliminated, they are excreted through the sebaceous glands as extra sebum. Thus one experiences “oily” skin. The skin naturally has a number of blocked pores at any given time, either because of dirt, unshed skin cells or solidified sebum, but the normal output of oil is so low that there is little appreciable build-up of oil behind the blockages. In the case of excess sebum secretion, blocked pores quickly become flooded with sebum, creating a buildup that not only causes a noticeable bump or “comedone”, but also an environment where bacteria may flourish, sometimes causing the pore and surrounding skin to become infected.

By supplementing extra B5, the body’s B5 pool is brought up to an adequate level, resulting in more thorough fat metabolism: after covering the hormonal and neural aspects of the body’s needs for B5, there’s still plenty to go around to burn off the fats. So instead of excess fats ending up as extra sebum (and eventually resulting in acne) they are burned for fuel. No extra fats means reduced sebum output, and thus less likelihood of acne.

It is important to note that there are many reasons a person may be deficient in B5, and any combination—or all—could apply. Our world today, unlike the world of our ancestors many thousands of years ago, has high levels of pollution in our land, sea and air, which takes its toll on us. Pollution is a type of stress that our bodies must deal with on an ongoing basis, through stepping up action of the immune system, eradicating free radicals, removing toxins, and so on. However, we are also affected by the food we eat. Humankind evolved for millions of years on a diet that consisted mainly of animal flesh, fruits, and non-starchy vegetables. Today we have an abundance of food, but much of it contains grains and dairy, or is processed with salt and other chemicals, things that were never staples of our diet. If we start out in life eating foods that are nutritionally deficient or incompatible with our digestive systems, those deficiencies will give rise to various diseases and disorders as we mature. Acne vulgaris is one of these diseases—it reflects a deficiency of B5.

Many of the foods we eat today have varying and sometimes unpredictable effects on our bodies, aside from causing deficiencies. Refined sugar (among other high-glycemic foods), for example, causes a spike in insulin levels, and as we are coming to realize is a prime factor in the cause and prevalence in diabetes and obesity. Refined sugars in the diet not only raise insulin levels, but they have also been linked to increases of cholesterol and triglycerides (fats) in blood serum as a result of the sugar’s conversion to fructose (and to some degree, sucrose) in the bloodstream. There are many factors at work here, but suffice it to say that when the body is fed carbohydrates with a higher glycemic index, it will use those carbohydrates first for a quick and easy energy burn (it should be noted that this method of obtaining energy is actually quite inferior to that of obtaining energy from fats), and since this involves a different process than that normally used to burn fats for fuel, those fats that would normally be used up are left mostly unmetabolized and must be dealt with, which depends a lot on the amount of B5 available to form CoA. Though some fats do still manage to get metabolised this way, some of the excess are stored through the action of insulin, and the remainder must be excreted (sebum being one of these excretion methods). Thus it is possible to see the correlation between sugar and acne, though it must also be noted that most fruits and vegetables do not cause an increase in cholesterol and triglycerides because they include enough dietary fiber to delay entry of carbohydrates into the bloodstream (giving them low rankings on the glycemic index). To illustrate this, consider your typical chocolate bar and its effects on acne: it has a high content of fats and refined sugars, and practically no dietary fiber to speak of. So by eating the chocolate bar, you get a number of bad effects, namely a large spike in insulin levels, increases in blood cholesterol and triglycerides, and on top of that all the extra fats that the chocolate bar contains aside from the sugars having the previous effects, so then there’s even more fat that the body must deal with through excretion.

Puberty is another example of the body’s increased need for B5. During puberty, the body is flooded with hormones—it’s no coincidence that puberty is also when most people first experience acne! The production of all these extra hormones means a drain on the body’s B5 pool. Any situation that involves a rise in the body’s hormones means a greater possibility of a B5 deficiency, resulting in acne. Puberty, pregnancy, use of anabolic steroids, caffeine intake (increases adrenaline levels), etc, all cause a greater hormonal output. By supplementing with extra B5, we can ensure that there will be enough left over to properly metabolize fats and keep our skin clear.

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3. Is B5 safe?

There have been many tests with B5 conducted over the years, all indicating its inherent safety2, even in high doses. Because B5 is a water-soluble vitamin, it does not collect in bodily tissues. Instead, the body takes what it can use, storing some small amounts in the heart, liver and kidneys, and rapidly excreting any excess. Compare this to a fat-soluble vitamin like vitamin A, which does collect in bodily tissues and can build up toxicity over time if too much is taken. B5 has even been given to animals and humans in doses of up to 1 gram per kilogram live weight, with no harmful side effects whatsoever! For a 70-kilo man that would equate to about 70 grams per day, far above the maximum of 15 grams currently recommended for acne treatment.

There have been some discussions that large intakes of B5 might throw off the balance of other vitamins in the body, specifically zinc. Though there has not as yet been any documented evidence to this effect, it is recommended that a multi-vitamin be taken regularly when dosing with B5, if just to ensure that all the bases are covered; not everyone eats healthily enough that they may get all their vitamins from food alone, though this site highly recommends making the effort to adhere to such a diet (see “The Paleolithic Diet3”).

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4. Are there any side effects?

When initially starting a B5 regimen, or when significantly increasing one’s dosage, there are some small negative side effects that people may expect to experience. The most common—as with many vitamins sometimes given in high dosage, like vitamin C—is diarrhea. This usually lasts for a couple of days at most, and is relatively mild. Other minor side effects may include increased hunger (“gnawing” sensation in the stomach), tiredness at odd times, and more rarely, headaches. The “gnawing” sensation in the stomach and the tiredness, as this author and others experienced, were infrequent, and totally absent after the first week of B5 supplementation. Most of those who experienced headaches report that their headaches either dissipated within a few days of starting B5, or after they increased their water intake.

The good news is that there are a number of positive side effects people have experienced while supplementing with B5. The most noticeable was an increase in energy levels. The energy boost may easily be attributed to the body’s metabolism shift to burning more fats for fuel. The body in fact prefers to burn fats for energy (not to be confused with “ketosis”, by the way, which is a dangerous state for the body to be in). When the body derives energy from fats, the energy source is more constant, and the blood sugar is not subject to the fluctuating peaks and valleys normally experienced when deriving most of one’s energy from complex carbohydrates, such as those found in grains. With fats, there is an even energy burn all day. Many athletes are coming to realize the benefits of deriving energy mainly from fats instead of complex carbohydrates, in that there is more glycogen and ATP being made available for muscular performance. Aside from increasing energy reserves, B5 promotes a positive nitrogen balance in the body, which is essential for the purposes of building muscle; athletes and bodybuilders are catching on to this fact as well.

A boost to the immune system may also be seen with B5 supplementation. Again, B5 has many different (and critical) functions in the body, among them tissue repair and immune function. Anecdotal reports from B5 users indicate shorter recovery times from illness and wounds. Animal studies also indicate an improvement in overall health, not only in the eradication of various B5 deficiency-related diseases, but improvements in already “healthy” animals.

Other positive reported side effects include vivid dreams and increased mental alertness, both of which (in addition to the athletic benefits mentioned above) this FAQ’s author has had the pleasure of experiencing.

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5. How much B5 should I take?

In Dr. Leung’s original acne study, subjects took from 10 to 15 grams per day orally, though they did also apply a B5 topical cream to affected areas. The cream may help (B5, like other vitamins, can be absorbed through the skin), but most people who have used B5 have so far reported that the oral form (capsule or powder) is excellent on its own. In cases of severe acne, and complicating factors (like seborrheic dermatitis), topical B5 is recommended in addition to oral dosing.

It is generally suggested to begin dosing with B5 in the mid-range, at around 4 to 5 grams per day. From there it is easy enough to see how well the initial dose is working, and it can be increased or decreased from there. Some people will have the need to go up to 10 grams per day, depending on the rate of clearing in their skin. Some people will have satisfactory results on only 5 grams, and may be able to decrease their dose to a minimum maintenance dose that keeps them clear (and saves money on B5 at the same time); some people have reported a minimum daily maintenance dose of as little as 250mg to keep their skin free of acne. Some, like the author of this paper, are at the other extreme, and require up to 15 grams of B5 per day for many months. What matters in determining B5 dosage is individual need based on initial B5 deficiency, genetics, exposure to pollutants and other bodily stresses, and diet. The trick is to use observation to determine the minimum dosage you need to take to get the results you want. B5 isn’t expensive, especially in powder form, but at 15 grams per day the cost can add up (though compared to the alternative—acne—it may very well be worth it).

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6. When and how should I take B5?

It is highly recommended to take your doses of B5 divided up evenly over the day. For example, if you’re taking 6 grams of B5 per day, you would do well to take six 1-gram doses, spaced out as evenly as possible. The reason for spacing out your doses is that the body can only make use of so much B5 (or any nutrient) at a time. Trying to take the 6 grams of B5 all at once would really only result in a waste of the excess that the body can’t absorb, and it wouldn’t allow much coverage for your body’s B5 needs throughout the rest of the day. The ideal might be to take as many small doses throughout the day as possible, but it isn’t always practical to take doses on every hour or half-hour. Every two or three hours appears to work best for most people.

It is up for debate of whether to take B5 with food or not. One contention is that the simultaneous absorption of certain other types of vitamins (B6 & B12 for example), either from food or supplements, can interfere with B5’s absorption. You may want to try taking your doses at least 15 minutes before a meal, or a minimum of an hour afterward. Other recommendations state that B5 should be taken with food, though as of this writing it is hard to say why, unless it is thought that the food bulk will slow down the passage of B5 through the stomach and increase its absorption, or perhaps prevent any possibility of gastric distress. You will have to find what works best for you, if indeed there is any difference between the two methods. The author of this paper has taken B5 before, during, and after meals with no apparent reduction in B5’s efficacy.

Take B5 capsules with water, and B5 powder can be mixed into water quite easily, though if the taste of the powder is too noticeably bitter, a little added fruit juice can disguise the taste.

Here is a sample B5 regimen for a dosage of 15 grams per day, using 500mg capsules:

BREAKFAST: 5 capsules & 4 ounces of water.

MID-MORNING SNACK: 5 capsules & 4 ounces of water.

LUNCH: 5 capsules & 4 ounces of water.

AFTERNOON SNACK: 5 capsules & 4 ounces of water.

DINNER: 5 capsules & 4 ounces of water.

BEDTIME: 5 capsules & 4 ounces of water 30 minutes before sleep.

It is worth noting that the author has since discovered that taking B5 prior to sleep may result in interrupted sleep patterns due to a need to urinate; this may be caused either by the liquid ingested, and/or the B5; the body may be trying to eliminate left-over B5 in the urine. If you are sensitive in this way, you may want to take your last dose of B5 several hours before you plan to go to sleep, thus ensuring that you get a full night’s rest.

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7. How long will it take for B5 to clear my acne?

This is entirely dependent upon your own unique situation. People with severe acne can expect total clearing to take longer than for people with mild to moderate acne. In the original study conducted by Dr. Leung, some people took up to six months to be acne-free at 15 grams per day, whereas many cleared totally within a couple of months. And some people on low dosages will see total clearing in as little as a couple of weeks—perhaps less. Again, the factors involved are initial individual deficiency in B5, genetics, exposure to bodily stresses (like pollution), hormonal profile, diet, and sleep patterns4 (sleep is when the human body repairs its skin, so don’t deprive yourself!). As yet there is no definitive method to determine just how deficient in B5 a person is; if one goes by the vastly underestimated U.S. RDA, it doesn’t seem possible that anyone could be deficient in a vitamin that is recommended at a minimum of only 10mg per day, though in most parts of the world acne is not yet recognized as a disease caused by deficiency in B5. Obviously, a little bit of trial and error will be required for you to hit upon the dosage that gives you the results you want.

At the risk of sounding too obtuse, you may or may not have to supplement B5 longer than 6 months, or even for an indefinite period of time (perhaps years). Studies longer than 6 months have not yet been published. There have been reported cases of people whose acne cleared up and who did not need to supplement B5 afterwards to remain acne-free. But its also possible that you will need to take in a regular daily maintenance dose to stay clear of acne. The goal is to get your skin to the point where it is consistently clear for several months, after which you can begin scaling down the dosage to see what your minimum dosage requirement is.

When beginning a B5 regimen, expect to experience visible improvement at a given dosage in at least two weeks. Yes, some people see clearing within a week, or even within a few days, but this isn’t really the norm. If within two weeks you see no improvement, then increase your dosage (depending on where you began, you may want to double the dosage, i.e., from 5 grams to 10 grams) for another two weeks. When taking B5 for acne, the virtues of observation and patience offer compelling rewards.

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8. Why can’t I get enough B5 from food?

B5 is present in most foods, which is no surprise given that B5 is essential to all living cells. But the amounts available to humans are tiny—only a matter of milligrams. B5 breaks down with excess heat, so cooking inevitably robs our food of some B5, as do certain food processing methods and storage conditions. When you consider that acne treatment can require up to 15 grams’ worth of B5 per day, you see how pointless it would be to try to get even 1 gram of B5 per day from food alone; the sheer bulk of food involved would be too much to consume. Here are examples of B5 levels present in some common foods:

B5 Content of Selected Foods, in Milligrams per 3 ½ oz. (100 gm) Serving

Yeast, brewer’s
Oatmeal, dry

Yeast, torula
Buckwheat flour
Brown rice

Liver, calf
Sunflower seeds
Whole-wheat flour

Peppers, red chili

Rye flour, whole

Soybean flour
Blackeye peas, dry

Split peas
Wild rice

Wheat germ, toasted


For people without a B5 deficiency, natural foods provide all the B5 their bodies need, just as nature intended. But many of us do have a B5 deficiency, for any combination of the reasons discussed previously. Some of us may get over our deficiencies, and some of us may have to treat them on an ongoing basis. In either case, megadoses of B5 are needed, and it just isn’t possible to get those levels of B5 from food alone. Supplementation is essential.

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9. Isn’t Coenzyme-A inexhaustible (so why should I need more B5)?

This is an interesting question that has been brought up many times before. Coenzyme-A acts as a catalyst to various chemical processes in the human body. Catalysts don’t take part in a chemical reaction themselves—they just get the ball rolling, so to speak, and are thus technically thought to be inexhaustible. While this may hold true for metals and certain synthetic compounds, this doesn’t hold true for organic molecules like enzymes. They are subject to breakdown from heat and other chemicals, and some amounts may also leave the body during elimination. If CoA truly never broke down, we would have had all the B5 we’d ever need long before we’d ever left childhood. According to medical science we still have basic B5 requirements every day of our lives, so obviously CoA doesn’t last indefinitely. No one yet knows for sure why CoA seems to have such a high turnover rate in some people and not in others, but it is likely that genetics, stress and pollution are mitigating factors. Doubtless we will eventually know, and the root causes can then by addressed. Until that day comes, mega-dosing B5 is a viable and highly effective option.

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10. Does diet matter when taking B5?

Absolutely! B5 can help you recover gracefully from the occasional slip, but a steady diet of junk food is only going to work against the B5 (and you).

Despite the fact that many doctors and dermatologists claim that there is no link between sugar and acne, a link does in fact exist. Sugar, in and of itself, has no directly appreciable characteristics that induce acne. However, it is sugar’s effects on the body’s blood chemistry that leads to acne, as discussed in question number “2” above. The more refined sugar you eat, the more your body’s B5 pool is depleted as the body attempts to cope with raised levels of blood triglycerides through action of CoA. As discussed earlier in how B5 supplementation treats acne, when the body is low on B5 the processes that are more critical for survival are the ones to which the available B5 is allocated. Other processes, like lipid (fat) metabolism, receive a secondary importance, and thus any remaining B5. If there isn’t enough B5 to process all the fats, either because B5 levels are low to begin with or because dietary intake of high-glycemic foods is increasing the need for B5, unprocessed fats are excreted through the skin as excess sebum, which in turn leads to acne. For more detailed information on the glycemic index and how sugar affects the body, you may want to read the book Sugar Busters5.

Fats and oils should not be taken in excess. What defines “excess”? This can vary from person to person, but typically any fats you don’t get directly from whole, natural foods can be seen as excessive (despite the erroneous suggestions of the “Food Pyramid”, grain and dairy products do not fall under the “natural” category for humans). Processed foods tend to contain a lot of fats—some natural, some unnatural, and many are unhealthy for you despite being derived from “natural” sources. For more information on how human beings really ought to eat, you may want to read The Paleo Diet3. From what you’ve read here so far, you know that the body has to deal with excess fats, but this doesn’t mean that you should try to cut all fats out of your diet, nor necessarily aim for a “low-fat” diet. If you’re eating properly (as explained in “The Paleo Diet”), your body will be burning fats for energy, which are its preferred energy source (not to be confused with “ketosis” which is dangerous), instead of storing them around your middle. For some people, like the author of this FAQ, fats are best derived from natural animal sources (meat), and/or nuts (such as macadamia nuts); even though oils like olive oil have been deemed as “healthy” by many mainstream nutritionists and doctors, they can often exacerbate acne (again, such as this author has experienced). A little trial and error will indicate whether you can handle oils as a regular part of your diet, or if you can only have them occasionally, if at all.

Other substances that artificially change the body’s hormone profile should also be avoided. Caffeine raises adrenaline levels. Nicotine, aside from being an outright poison, inflates levels of the neurotransmitter serotonin, and it loads your body with toxins, which impacts the immune system, which in turn depletes B5 even more. Anabolic steroids pump the body full of unnaturally high levels of testosterone. You get the idea. All of these things cause a drain on the body’s reserves of B5, so if controlling your acne is a priority, you’ll avoid these substances. You’ll also do well to avoid emotional stress when possible, which will not only reduce the levels of B5 drained away to regulate hormonal flux, but will benefit your psyche as a whole (this goes without saying). Learn to deal with stress if you can’t avoid it—take deep breaths, exercise, meditate—whatever works for you. To paraphrase Edward Norton’s character from the movie Fight Club, you have to learn to let the things that don’t matter truly slide. However, all this doesn’t mean you need to go around in a state of “neutral”—things that make you happy will benefit your body chemistry and your psyche in a multitude of ways I cannot even begin to recount here.

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11. Will B5 decrease the size of my pores?

If your pores are enlarged because of increased amounts of sebum flowing out of them, then yes, B5 will help reduce pore size. How? Each pore is ringed and regulated by tiny muscles that can expand or contract the pore opening. When your skin is excreting more sebum than normal, the pores expand to allow the sebum to flow out. Dirt, debris, and hardened sebum can also remain trapped in the pore, keeping it expanded. When you take B5, the excess fats that would normally be pumped out of the pores as extra sebum are metabolized instead, decreasing sebum flow, which eventually leads to a reduction in pore size. Granted, genetically speaking, some people may have larger pores than others, but if your skin is excreting more sebum than is natural for you, then your pores are quite probably larger than they should be. The amount of sebum normally needed to keep the surface of the skin moist is rather minute, and pores are naturally very fine and tight. However, don’t expect your skin’s pores to shrink overnight. They will gradually contract as less sebum is produced, coinciding with your B5 regimen. It is not uncommon, however, to see a difference in pore size within a couple of weeks of an effective B5 dose.

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12. Can I take B5 during pregnancy?

This is a touchy subject at best. I’ll say up front that no drug company, doctor, or supplement retailer wants to go on the record as recommending anything during pregnancy beyond the typical, documented advice and established RDAs. The irony is that a lot of documented advice is derived from cases where pregnant women have taken it upon themselves to use a particular drug or vitamin during their pregnancies, all at their own risk, as doctors don’t want to end up getting sued for experimenting on unborn babies. There are just too many risks of lawsuits for anyone to want to take a chance to recommend something that hasn’t already been studied during pregnancy ad infinitum. If you are pregnant and you decide to supplement B5 during your pregnancy, you will have to do so at your own risk.

That said, I will now point out some anecdotal observations. Dr. Leung had a number of pregnant patients who, of their own accord, decided to keep supplementing B5 during their pregnancies. None of the women showed any ill effects, and their babies were all born healthy. It’s important to keep in mind the science behind the treatment here. It’s too easy for people to have a knee-jerk reaction on this subject because it involves babies. B5, as we already know, is a non-toxic, water-soluble vitamin. What the body can’t use, it passes out of the body. So in the case of pregnancy, the body will take what it can use for the developing fetus, and for the mother, and that’s it. B5 doesn’t collect in bodily tissues like, say, vitamin A, so there’s no reason to think that it could build up and somehow pass into the womb en masse. It just doesn’t work that way. Many women already supplement vitamins during pregnancy, not all of which are water-soluble, and they do so without any apparent ill effects.

Pregnancy is a time when the mother’s body is flooded with hormones. Women experience any of a range of symptoms during and after pregnancy, among them acne. Acne, as we know, is a symptom of B5 deficiency. Rational thought would conclude that it makes sense to supplement B5 during pregnancy when such symptoms occur. Besides, wouldn’t a woman be better off with extra B5 than not enough, since we have no idea what a deficiency in B5 might do to a baby? In actual fact, it is generally recommended by doctors that women increase their intake of B5 (among other vitamins) during pregnancy, though the typical recommended amounts are miniscule at best. If you decide to supplement B5 during pregnancy, make your own educated decision based on science and evidence, not on alarmist rantings.

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13. How well does B5 really work?

You won’t know until you try it. By now you know that everyone’s needs are different. But what you can indeed expect is to find a dosage anywhere up to 15 grams per day (except in more extreme cases) that will keep your skin clear of acne while decreasing oiliness. Yes, it takes a little bit of trial and error to find what regimen works best for you, but compared to walking around with full-blown acne, this process is relatively painless. You will have to weigh the benefits and arrive at your own decision of whether to give B5 a try or not. Compared to other acne treatments on the market, B5 is cheap, extremely safe, and highly effective at controlling acne. If you cave in to temptation and eat junk food every now and then, sure, you may get a few bumps on your skin because of it, but B5 works quickly to make those bumps not only disappear but also prevent them from turning into full-fledged breakouts. B5 is not only a source of prevention for acne, it is also great for damage control. If you’re eating right, and unless you have other factors complicating your acne vulgaris (like seborrheic dermatitis), you can expect to remain virtually acne-free while using B5.

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14. What if B5 doesn’t work for me?

If you try dosing up to 15 or even 20 grams per day with B5, and your acne still will not come under control, and you have given the treatment enough time (at least a couple of months at high doses to see some kind of visible clearing), then you may want to re-examine a few things: First—are you eating properly? I can’t emphasize this point enough—if you eat garbage, expect to look like it; B5 can only do so much to help you, so don’t sabotage your own efforts! Second—what brand of B5 are you using? Is it a well-known name-brand, or did you pick it up really cheap from some company nobody ever heard of before? If you have any doubts about your B5 supply, then make sure to buy it from a reputable company. Also be careful when storing B5, since heat and light can break it down, thus reducing its potency. Third—what kind of acne do you actually have? Is it acne vulgaris (“regular” acne), or is it cystic acne? If it’s cystic acne, you may in fact have a sensitivity or allergy to a particular kind of food. The author of this paper happens to get bad cystic acne after consuming oil & vinegar together (like balsamic vinegar) but at no other time. Monitor your food intake if this is the case. Also, there have been reported cases of B5 helping to control and even clear up acne rosacea and seborrheic dermatitis, but don’t expect this to happen overnight. The more complicated the case, the longer you should expect for clearing to take. Actual acne will appear to clear first, with various skin irritations and conditions taking longer to be improved by B5.

If you try B5 and it does not work for you at all, even at high doses, then there must be something more to your acne vulgaris than just a B5 deficiency. If you see any clearing at all with B5, though not total clearing, then the B5 will work for you, but you will just have to keep using it longer, and/or increase your dosage. If it really doesn’t seem to work at all, and you are paying strict attention to diet, sleep, etc, then there are other acne treatments available. However, without going into too much detail here, many of those “treatments” are Band-Aid solutions at best—they are supposed to be applied to existing acne in order to reduce swelling and clear up lesions that have already occurred. Antibiotics may work for a little while (if at all), but eventually the body grows resistant to them and your doctor will need to prescribe another antibiotic, then another, and so on (the author of this paper has experienced this nasty “merry-go-round”).

Accutane, a vitamin A derivative drug, has an effective track record for clearing acne and keeping patients clear, however it also comes with a host of possible side effects, some of which can be rather harmful in the near and long-term. Accutane may also only keep you clear for a couple of years, after which you may need another course to stay clear if by then your body hasn’t “gotten over” the acne. You will need to discuss Accutane with your doctor, since it is only recommended for use in cases where other legitimate means have been tried, and only then in severe cases.

Retin-A, also a vitamin A derivative like Accutane, but applied topically instead of orally, works by causing the skin to peel, thus keeping pores relatively free of dead skin blockages and looking “new”. It is important to note that Retin-A may have bad side effects for some people (though not necessarily all), such as redness, excessive flaking, thinning and sensitization of the skin. This author has had seborrheic dermatitis for the past 13 years thanks to Retin-A’s side effects, so it is difficult to give an unbiased opinion of it here. Again, however, Retin-A falls into the “Band-Aid solution” category, since it is doing nothing to address the acne cause, just the symptom—even Accutane at least has a systemic effect that results in reduced sebum output (among its other physiological effects—not all of them good).

When you try B5, approach your regimen with discipline and purpose. If you have acne vulgaris, B5 can keep your skin clear, but you have to give it a chance to work. If you do, I’m sure you’ll be very pleased with the results.

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15. Who discovered B5’s effects on acne?

Lit-Hung Leung, M.D. (originally at the Department of General Surgery at Hong Kong Central Hospital) discovered B5’s anti-acne effects on test subjects while conducting a study to determine B5’s effects on dieting and obesity while supplementing B5 on a reduced-calorie diet. His study on B5 and obesity was published in 1995. After conducting a subsequent study on B5’s effects on acne alone, Dr. Leung later published his paper on B5’s effects on both acne and obesity in 1997. Dr. Leung is still conducting B5 research. You can e-mail him at: [email protected]

If you have any questions about B5 that have not been answered in this FAQ, or any suggestions or comments, you can e-mail the author of this FAQ here: [email protected]


Related Acne Archive Posts & Questions

17 thoughts on “More B5 Info

  1. Wally,
    This is a very interesting post because you have Dr. Leung’s e-mail listed at the end of the post. This is the first time I have seen Dr. Leung’s e-mail posted. Are you going to send him an e? I think you should. I think he would be an interesting person to correspond with, and you could probably learn more about the subject. Then you could let all of us know what he had to say.

  2. Thanks Solomio. I was thinking about it, but then I don’t know what I would ask him. I am going to post some more information, email responses he gave to some people. I know this is a lot of info, but even if people can read just a little bit they will be better informed. I think the Roche (Accutane maker) link is kinda cool, but they go really in depth.

    Below is correspondence one had with Lit Hung Leung. This isn’t copywrited information, so it should be fine to post here.
    — Frank (last name removed) wrote:
    > Dear Dr. Leung,
    > Thank you very much for your mail – it was great to
    > hear from you!
    > Yes, pantothenic acid is definitely curing my severe
    > acne and I have to tell you how grateful I am for
    > your
    > research and your finding of this cure!
    > The bowel sounds are a side effect that I have been
    > experiencing since first taking PA. Now, after one
    > year, I have the impression, that the gurgling gets
    > worse and that I also have stomach pain and diarrhea
    > sometimes. I am going to change the kind of B5 pills
    > I
    > am taking (I was taking time release capsules of 1
    > gram up to now) and hopefully this will end my
    > stomach
    > problems. If you have any other kind of advice for
    > me
    > on the topic it would be great if you could let me
    > know.
    > What I also would like to ask you: Are you
    > recommending to supplement the intake of B5 with
    > other
    > B-Vitamins in order to avoid a vitamin-deficiency of
    > any kind?
    > Thanks in advance for some feedback on these points.
    > It is definitely wonderful to get in contact with
    > you
    > and get some advice on my PA-therapy because of
    > course
    > it is useless to see a doctor here in Germany about
    > this.
    > All the best to you and your further research.
    > Best regards,
    > Frank

    Dear Frank,

    Thank you very much for your letter in which you
    raised a most interesting point. You asked if I
    recommend supplementing the intake of B5 with other B
    vitamins in order to avoid vitamin deficiency
    syndromes of any kind?

    From the e-mails that I recently received, I find that
    this is a point that I need to make clear and to
    expound on. My whole concept on nutritional therapy
    and vitamin supplementation is based on the idea that
    what vitamins that we take in from our foods are not
    enough to provide the body to function at its optimal
    state of health. The junk foods that we so commonly
    have, the fast foods from chained stores, the canned
    foods that are from the supermarkets do not have the
    sufficient and necessary essential dietary factors
    that the body required for maintaining good health.
    These kinds of foods are not the fresh foods that our
    body is supposed to have.

    On top of these, there are the unwanted and toxic
    materials that we constantly take in from our
    environment. Examples are easy to come by and they
    include he cigarettes that we smoke, the preservatives
    that are in all those foods that are not
    freshly-prepared, the alcohol that we drink and the
    polluted air that we breathe in. For the body to
    function at its optimal state, these toxic matters
    need to be removed. This removal process, or
    detoxification process, involves chemical reactions
    that will deplete the body of its reserves of vitamins
    and essential dietary factors. This is very much like
    keeping our cities clean in actual life. A city can be
    kept perfectly clean even if everybody is littering,
    provided that the city council can free up resources,
    in this particular case, money, to have enough workers
    to do the cleaning job. This process will drain
    resources that will no doubt pose a burden on other
    equally important projects. The same is true with the
    body. When the cells are drained of their resources
    in the detoxification process, they are not going to
    work as efficiently as before. In order to maintain
    their efficiency, the vitamins and others depleted
    need to be replaced.

    And it has to be recognized that there is no
    guarantee that the body is able to clear of all those
    toxic materials, some of which probably will slowly
    accumulate in the body cells. Over time, these will
    pose a burden on the functioning part of the cells,
    and the cell will become less healthy and probably die
    sooner. This is probably the principle behind the
    aging process the mystery of which is what the
    scientific community strives to find out. This only
    shows that a healthy eating habit, in which all those
    substances that are detrimental to the body are
    carefully avoided, is of paramount importance to our
    health. And it is obvious that vitamins and essential
    dietary factors, important as they are, are not the
    only things that the body needs. With this in mind, we
    can easily see the pitfall in cases in which junk food
    is the staple diet and ample vitamins and dietary
    factors are taken as supplements. When we talk about
    vitamins and essential dietary factors, we are
    referring to those that we know, without taken into
    account those that we do not know. It is almost
    certain that there are vitamins and essential dietary
    factors that have not been recognized as yet. And as
    such, there is no way to supplement these unrecognized
    dietary factors the way we supplement our diet with
    individual vitamins and the like. The only way to do
    that is to have a wide variety of fresh foods of all
    kinds, so that whatever is required will be taken in

    It now becomes clear that the answer to the question
    if I recommend supplementing the intake of B5 with
    other B vitamins in order to avoid a vitamin
    deficiency syndrome of any kind is a resounding “yes”.
    Yes, B5 is very important. But it is not everything,
    nor is vitamin C. All vitamins are important, so are
    the other essential dietary factors. The crux of the
    problem here is not if vitamins are required, it is a
    problem as to how much that is required. What is the
    optimum amount of the vitamins that one should take?
    The FDA provides us with an answer. However, Linus
    Pauling, in his scientific and methodical manner,
    showed that the dosage recommended by the FDA, as far
    as vitamin C is concerned, is far from enough. He
    recommended dosages that are hundreds of times, if not
    thousands of times higher than that is recommended. It
    is unfortunate that the medical profession and the FDA
    fail to see his point and decide to disagree with him.
    The incomplete understanding of the basic biochemical
    reactions involving vitamin C seems to be a
    contributing factor here. The lack of changes of
    something very obvious, something very noticeable in
    those who are taking it are another reason why the
    controversy seems to go on and on.

    With pantothenic acid, things look a lot more
    different. Thanks to previous researchers working on
    pantothenic acid, the basic biochemical reaction of
    the vitamin had been worked out. We know that the role
    pantothenic acid plays in the body, or rather in the
    cells, is by incorporating itself with adenosine
    triphosphate and cysteine to form coenzyme A, which is
    commonly recognized as the most important coenzyme in
    the body. It is every where. Whatever food we take in,
    we will need pantothenic acid in the form of coenzyme
    A to convert it into energy. And in the acne
    processes, thanks again to research workers on the
    field, we know almost all the facts and clinical
    presentations of the disease process. The only problem
    is that, previously, no one is able to string all the
    facts together. Any theory that is proposed, there are
    bound to be paradoxes coming up that are impossible to
    explain. Controversies are everywhere. But, with
    pantothenic acid, most of the facts can now be strung
    together and explained, and explained in a logical
    manner. What is more, it is now possible to note the
    relationship of dose and effect. It is noted that in
    some patients, 10 gm a day is not even sufficient to
    combat the disease process, making the number 10 gm
    not as ludicrous as people might first think. When
    talking about taking 10 gm of vitamin C a day, despite
    Pauling’s reassurances, people were talking about side
    effects. Well, no side effect is noted for those who
    take long-term, high dose vitamin C supplement. The
    same is true with pantothenic acid. I have people
    taking 5-10 gm a day, myself and my family included,
    for over ten years now, and no side effect is ever
    observed. They all become healthier, and the skin
    quality much improved. And I would add that this
    improvement seems to go on for as long as the vitamin
    is taken. Why the medical profession, and the
    dermatologists in particular, fails to embrace this
    theory, intentionally or otherwise, is beyond me.
    Before long, I may find this theory attacked by the
    conventionalists. This sort of things has happened
    before. When I think of the fate of Copernicus and
    Galileo Galilei, I am quite at peace with myself.

    The importance of pantothenic acid and acne goes far
    beyond this. It is the very first time that one is
    able to show, beyond any doubt, that the requirement
    of pantothenic acid is a lot more than is commonly
    thought, at least in acne cases. If we are going to
    extend the argument and ask ourselves: Is this the
    only vitamin that is required in large amounts to make
    people feeling better and healthier? Logic will tell
    us that this can hardly be so. It is probably true
    that the requirements of all the vitamins are a lot
    higher than what is recommended by the FDA, the only
    problem that remains is the amount that is required.
    It is likely that this will vary widely from
    individual to individual. But to settle this question,
    we will need the concerted effort of research workers,
    nutritionists, and the medical profession as a whole.

    There is just one more point to address here. If B5
    and other vitamins are going to help to improve the
    general well being of an individual, will, by taking
    all these vitamins together, help to improve the acne
    condition better? To understand this, we should have a
    broader view of metabolism in the body as a whole. At
    any given time, there must be thousands and thousands
    of chemical reactions going on in the body. It will
    need a huge flow sheet to chart down all these
    chemical reactions, which, at this stage when so many
    metabolic pathways are still unknown to us, will be
    impossible. But there is something we know. We know
    that some of these chemical reactions will affect
    other reactions. And that the direction of a reaction
    is many a time determined by the substrate
    concentration, the concentration of various enzymes
    and coenzymes. So it is a very complicated picture. We
    know the body has a finely tuned auto-regulating
    mechanism working as a whole at an attempt to make the
    individual a healthier one. In the best of conditions,
    the body will be maintained at a healthy state. In
    cases of shortage of raw materials, vitamins and
    essential dietary factors included, the body will do
    some sort of rationing the best it can, to maintain
    the body at as healthy a state as it possibly can,
    sacrificing some reactions that are not vital for its

    This is exactly what happens to a body that is
    deficient in a lot of vitamins. And we know most of us
    are deficient in vitamins to some degree. Adding some
    vitamins to the body, the reactions will be shifted in
    a way that will serve the body best, which may not be
    to the best interest of the acne process. The reason
    is that the acne process is not considered to be
    something that has a lot to do with survival. So that
    raw materials that need to deploy to deal with the
    acne process are axed, to the betterment of the body
    as a whole. My experience supports this theory. I have
    seen patients whose acne got a lot worse when they
    started taking multivitamin capsules. These were the
    days before I started treating acne patients with
    pantothenic acid. Similar things happened to some, but
    not all patients when I started treatment of acne with
    pantothenic acid. This is particularly noticeable when
    some of these patients are having a relatively large
    dose of B6, say 200-300 mg a day. It is quite possible
    that there are other vitamins that will influence the
    acne process adversely. It probably varies from
    patient to patient, and I will need all feed back that
    I can have to compile my data. This is the reason why
    I urge all those who take pantothenic acid to notice
    any changes in their condition after taking the
    vitamin, and have them noted down, and reported back
    to me. It will help me tremendously in my research

    This is a lengthy reply, but I hope I have answered
    your question.

    Lit Hung Leung

  3. More responses from Dr. Leung:
    January 24, 2002

    Dear Dr. Leung,

    Your research on pantothenic acid (vitamin B5) has changed my life.

    For the past 13 years I have suffered from seborrheic dermatitis (facial) brought on by Retin-A, prescribed for acne while I was still a teenager. The Retin-A ruined my skin and failed to get rid of the acne, which I have also suffered from well into my adult years.

    This past November, an acquaintance of mine told me how people were reporting to the alt.skincare.acne Internet newsgroup incredible stories of some “miracle” vitamin that was curing their acne. I almost dismissed the idea out of hand as yet another fad that would ultimately lead to disappointment, but something inside me made me investigate anyway. What I found was a growing tide of people who had discovered your research into B5 and were reaping great benefits from it. This great tide is still growing, and I do my best to encourage it whenever I can, because B5 has given me something that I thought was almost dead for me: hope.

    I am writing to you now because I want to be sure that you know your research has made an impact. Your research has allowed acne sufferers like myself to rekindle their self-esteem. Your research has allowed acne sufferers like myself a chance to “fit in” and possibly live “normal” lives.

    Unfortunately, I must also tell you that there are detractors who seem bent on pushing people away from B5 and toward drugs like Accutane and Retin-A. These people act like they must work for the drug companies, as evidenced by the zeal they express when discrediting you and your work. Of course the drug companies have much to fear from you and B5–they make millions of dollars selling their acne “treatments”, regardless that their treatments are garbage and, in cases like Accutane and Retin-A, dangerous. Something as safe and effective as B5 is a threat to their prosperity. And of course there are also a few start-up companies who have swung the other way and are trying to capitalize off of your research by offering products that contain B5, or are “superior” derivatives of B5, and so on. What will eventually happen is that the major vitamin supplement manufacturers will catch on to the rising tide of B5 and seek to capitalize on it themselves. All well and good in the name of capitalism. But what is also bound to happen is that somewhere along the way, B5 will be inaccurately blamed on some health crisis or other and possibly restricted or even banned as a supplemented vitamin–it happened in the United States with L-tryptophan, an amino acid that was wonderful as a sleep aid, but that a company altered the formulation of and ended up killing several people with a tainted batch.

    I hate to sound ungrateful for what your work has already done for me, but I must ask something more of you. I ask that you defend your work, possibly on the alt.skincare.acne newsgroup, and/or possibly through mainstream news media. I also ask that you continue your research on B5 and acne, so that the exact underlying process at work can be confirmed, and all possible side effects accounted for at high dosages, thus laying all the detractors’ arguments to rest. You would be doing a great service not only to your own reputation, but to the very people your research has already helped and to the people who have yet to discover it.

    Here is a brief summary of my own B5 use:

    · Started November 10th at 5 grams per day

    · After noticeable acne clearing, increased dosage after 1 week to 10 grams per day

    · After another 2 weeks of more dramatic improvements, increased dosage to 15 grams per day, and maintained daily dosage to present

    I spread my B5 intake over the day, divided into 6 x 2.5 gram doses. I’ve found the B5 seems more effective if I don’t take it with food, but rather take it at least 10-15 minutes before a meal or at least an hour afterward. I currently use TwinLab brand, 500mg B5 capsules.

    My improvements have been that I now get virtually no acne…except if I eat a lot of sugary and/or oily food, in which case the few acne bumps I do get are extremely minor and disappear quickly, never getting infected. My skin is still slightly oily from the seborrheic dermatitis, but it is no longer as red and irritated as it used to be, and the dermatitis seems to be gradually fading.

    The only negative side effects I noticed were minor diarrhea at first, accompanied by hunger cravings, both of which disappeared after a few days (the diarrhea after about 2). I did notice the diarrhea effect again when I increased my dosages, but it again disappeared after a couple of days.

    I have noticed at least two positive side effects: increased energy throughout the day, and what seems to be a boost to my immune system; I have been exposed to all manner of colds, flu, and illness this winter and have not gotten sick, whereas normally I would have gotten at least a couple of colds.


    William G. Gray

    ————Dr. Leung’s first reply———

    Dear Mr. Gray,

    Thank you so much for your very encouraging letter of
    January 24, 2002. I receive your letter only today.
    There is an reason for this. I have left Hong Kong
    since 1997, when the former British Colony was
    returned to China. I am now permanently residing in
    Bryn Mawr, Pa, which is but a few hours’ drive from
    where you live. The place that your letter went to
    belongs to a very good friend of mine. He is
    re-directing all the mails that are sent to me. It so
    happened that when your mail reached Hong Kong, they
    were out of town for something like 10 days. They were
    only able to fax your letter to me this morning when
    they returned from their trip.

    It is so gratifying to know that my work on
    pantothenic acid has helped so many, particularly so
    when you know that they appreciate what pantothenic
    acid has done for them, as all those letters that are
    sent to me can attest. I keep saying to myself that it
    is fortunate that this re-discovery of pantothenic
    acid is made in an era of Information Technology when
    the internet has made communication so easy, so that
    new ideas are not so easily strangled as in days of
    old. I am happy to hear that there are a lot of web
    sites talking about pantothenic acid, and of course,
    your are not the first one to tell me about this. But,
    up to now, I have not taken any role in these chat
    sites. I have my reasons.

    I am busy working on the effect of pantothenic acid on
    other aspects of human health. And I can tell you that
    I am getting on these other aspects quite well. Having
    live in America for nearly five years now, I have some
    idea about how things work here. The best thing is to
    have the results of your work published in a
    prestigious scientific journal. It is not enough for
    you to have your work published in any journal,
    because, many a time, the papers in journals other
    than first rate journals are simply ignored. This
    poses a particular problem for me. Not only am I
    working on something that is unconventional, but I am
    working all on my own without any attachment to any
    lab and any university, and to have anything published
    under these circumstances, even in a second or third
    rate journal will not be easy.

    The next thing that I can do is to write a book, and
    to have it published. To get a publisher with a wide
    distribution network is what I need. I have not looked
    into this as yet. The immediate problem is to write
    the book. As you are aware, I came from Hong Kong
    where, though English was the official language until
    the time I left, nevertheless, it is not as commonly
    used as many people outside Hong Kong would think it
    should. My mastery of the language, though good enough
    to allow me to express any idea that I want to convey,
    does not provide me with enough force to write a
    readable, good book. I am still trying to improve on
    my English proficiency, which is a rather daunting
    project but which is also something that I am
    determined to overcome. You can understand the
    challenges that are ahead of me. But I am sure I can
    overcome them all.

    Until not too long ago, I am not too comfortable with
    my language ability, and I am not sure whether it will
    serve me well in cases where I need to rebut whatever
    criticism I may have. Now, I am quite confident that I
    can do it, though it may not be in a way as effective
    as I want it to be. But the important thing is that I
    can do it. I am now ready to get into any chat site,
    and promote pantothenic acid the best I can, and to
    defend it if such occasions are called for. I also
    plan to have my own web site on pantothenic acid. For
    that purpose, I have already registered a web site, if
    I remember it correctly, that is called The web site is till in its budding
    stage, but I hope I’ll get it done quite soon.

    It is unfortunate that pantothenic acid, so important
    to the good health of the body, has not caught sight
    of the medical profession. They tend to think that the
    vitamin is so ubiquitous in the sense that whatever
    your diet may be, you still take in enough of it to
    serve your body well. They do not seem to realize
    that, as far as requirement is concern, to be in good
    supply is quite different from being just sufficient
    to stave away deficiency. To be in good health is
    quite different from just not having deficiency
    syndrome. I used to joke with my patients that to
    remain above the poverty line means that you are not
    going to starve, but that does not means that you are
    sufficient in everything, and a far cry from being
    affluent. There is a broad spectrum of requirement in
    everything, be it vitamin or money. The requirement of
    pantothenic acid is very much the same. People have a
    different requirement for the vitamin. Some may need
    many grams a day, though I can say that those who do
    not take pantothenic acid as supplement are, though
    not showing any symptoms, definitely in a certain
    state of deficiency, the only thing that varies is the

    In your letter, you asked me to defend my work. This I
    am certain to do. But I will also like to call on the
    help of enthusiastic people like yourself to help.
    Your letter tells me that you are somebody who is well
    educated, has a good command of the English language,
    well informed, and has good common sense and reasoning
    power. It is people like you that can help me to
    promote not only pantothenic acid, but nutritional
    therapy in general, for I can go as far as to say
    that, most diseases, aside from those that are caused
    by bacteria and virus and the like, are manifestions
    of a deficiency syndrome. You can give my e-mail
    address freely to anyone, friends and
    anti-nutritionists alike. But my objective is clear,
    to promote and to defend nutritional therapy, not the
    least pantothenic acid.

    I’ll talk to you again when I hear from you.

    Lit Hung Leung

  4. and advises on how to mix a B5 topical cream
    Thu Feb 21 2002 5:47:40 pm

    Dear Will,

    I am not familiar with the American market. I have
    been looking for some, as you say, neutral,
    water-based cream on the market for sometime, but
    without a lot of success. Some of the water-based
    cosmetic creams may work, but they are too expensive,
    and I find it not worthwhile doing it. Back in Hong
    Kong, I did have some cream base that would serve my
    purpose. But there is a very easy way out to serve
    your own personal needs. What I do is to dissolve a
    small quantity of pantothenic acid powder in sterile
    water, 20gm in 100 ml, or smaller quantities in the
    same proportion. I’ll apply the solution, which is
    very sticky that reminds you of honey, 6 times, or
    even more frequently a day with something like Q
    sticks. (For your information, honey has a very high
    content of pantothenic acid in it. That is as far as
    natural product goes. Its pantothenic acid content is
    of course far lower than the 20% by weight we are
    talking about.) This method has the advantage that it
    is inexpensive to produce, simple to prepare, and you
    can always make a fresh preparation in no time. If you
    eventually do find out some cream that would work, I
    would be grateful if you could let me know.

    Since you posted my e-mail address, I have already
    received 2 e-mails. I find janie’s letter interesting,
    and I have sent a copy of my reply to you. It contains
    something of wide interest. I hope you will be able to
    post my letter somewhere on the web.


    Lit Hung Leung

  5. Dr. Leung expounds further on B5’s safety
    Mon Feb 25 2002 11:27:03 am
    Dear Brenda,

    Thank you for your letter.

    I am a bit too busy answering all those e-mails that
    were sent to me in the past several days. I hope you
    have received the copy the original of which was sent
    to Will Gray.

    In that letter, I explained that you are at no risk at
    all in over stimulatin your adrenals with large doses
    of pantothenic acid intake, nor in any danger of
    adrenal shut down when you decide not to continue with
    pantothenic acid supplementation. The adrenal glands
    are factories, and pantothenic acid is one of the raw
    materials that the glands use in synthesizing their
    products. What is more, the human body has a very
    finely tuned auto-regulatory mechanism, and will only
    produce the optimum amount of product that the body is
    supposed to required. So Cushing’s is not a problem

    My experience is that most people, if not every single
    one of us, are deficient in pantothenic acid. The only
    difference in these individuals is the degree of
    deficiency. This is based on the observation that
    almost everyone who has taken pantothenic acid for
    only a short time, would invariably notice the
    improvement in the general health, and would feel
    better in general. I have many patients taking
    pantothenic acid over a long period of time. Not only
    do they not have any side effects, but that the
    improvement in their health, their skin condition seem
    to go on and on, in a slow but steady manner. The
    longer you take it, the better will the beneficial
    effects be. This is because pantothenic acid plays
    such a vital role in the metabolic process of the

    Much your worry in taking in large doses of
    pantothenic acid stems from some misunderstanding of
    the vitamin and its actions. I hope I have clarify
    your worries. But if you have more questions, do not
    hesitate to ask. I may add that many of your
    observations are correct, and I need all the feed
    backs from all those who are taking supplemental
    pantothenioc aicd for my research. So, can you note
    down all that you can observe, and have them feed back
    to me, and to your friends in the web?


    Lit Hung Leung

  6. Would B5 be able to be applied like those new drugs out there that you can use as patches? That way it could release a certain amount at a certain time? Or have those not come on the market yet?

  7. Yeah I’ve been reading this thread for the last 2-3 days…haha! and I’m seriously thinking about emailing Dr. Leung …’coz I dunno. B5 sounds great…but I’m just really scared about taking it for a long time…I mean who knows, for the next 10-20 years probably! ‘coz I know I wont’ be outgrowing my acne :cry I wish there was someone who took B5 for that long and could say that it didn’t cause them any side problems.

    Now, reading Dr. Leung’s emails in this thread, he compared it to taking 10 grams of Vitamin C. I know both B5 and C is water-soluble, so I see how he’s relating it, but they are totally different when it comes to their functions. Another thing is, would our body at one point get used to this B5 that it’ll stop working for our acne?? couldn’t that happen? especially when you’re talking about taking it for a looooong time?? Well I just wanted to post these thoughts here, but I”ll email him with these questions….now, I dunno if he still writes to people, but I REALLYYY hope he does!

  8. mickey

    He DOES right back, fairly quickly I thought too. I got an answer back in two or three days. I asked him a couple of questions, I think I still have the email’s saved, and he was really nice and polite. I’ll see if I can find those emails…..

  9. 1) Have you looked into the Chromium link to acne?
    > 2) What exactly is your occupation? ( This is very
    > nosy of me, you are not
    > forced to answer!). The reason I ask is that
    > vitamins and how they can be used
    > to treat acne and other problems is very interesting
    > to me. I am looking into
    > it as a possible career.
    > Thank you such much for your time, your responses,
    > and all of your research.
    > I wish you the best of luck in whatever endevours
    > you persue in the
    > future!!!!!

    I asked him those questions and he wrote back:

    Here is the answer to your two questions.

    1. I have never looked into any chromium links to
    acne. Tell me more about the links.

    2. I am a M.D. Trained in surgery and practised in the
    specialty for well over twenty years. Got interested
    in nutritional therapy and became a devotee to Linus
    Pauling’s teachings on vitamin C. Then I discovered
    the importance of pantothenic acid (B5) which to me,
    is a vitamin that has been grossly overlooked and
    under-researched by the medical community.

    It is my hope that those who benefit from the vitamin
    will tell their experience to as many people as they
    can, so that one day the world may wake up to this. I
    always believe orthomolecular medicine is the future
    of public good health, and a good starting point is B5
    because it is the only vitamin whose basic action and
    function have been worked out. That is why, everything
    that I said about acne and B5 is based on logic and
    sound reasoning. I do not have a shadow of a doubt
    that my theory will stand the test of time.

  10. Hi Wally,

    Your question about b5 treatment being used with patch therapy attracted interest.

    I do not think that b5 being absorbed subcutaneously would have much of an effect, as b5 does it’s job in the gastrointestinal system, hence the best method is by ingestion.



  11. I’m 15, will this work for me? I got sort of mild acne, but since it regulates hormones, would it stp me from growing anymore?

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