Emu Oil – DHT(Androgen)

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Research has shown that emu oil contains a high level of linolenic acid which further researchhas shown to be an efficient antiandrogen. Linolenic acid is a potent 5 alpha reductase inhibitor and may be usefull in the treatment of disorders related to the hormone Dihydrotestosterone. Linolenic Acid has been suggested to be of use in the disorders such as benign prostratic hyperplasma, acne androgenetic alopecia and hirsuitism.

TITLE
Inhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acids.

ABSTRACT
Human or rat microsomal 5 alpha-reductase activity, as measured by enzymic conversion of testosterone into 5 alpha-dihydrotestosterone or by binding of a competitive inhibitor, [3H]17 beta-NN-diethulcarbamoyl-4-methyl-4-aza-5 alpha-androstan-3-one ([3H]4-MA) to the reductase, is inhibited by low concentrations (less than 10 microM) of certain polyunsaturated fatty acids. The relative inhibitory potencies of unsaturated fatty acids are, in decreasing order: gamma-linolenic acid greater than cis-4,7,10,13,16,19-docosahexaenoic acid=cis-6,9,12,15-octatetraenoic acid=arachidonic acid=alpha-linolenic acid greater than linoleic acid greater than palmitoleic acid greater than oleic acid greater than myristoleic acid. Other unsaturated fatty acids such as undecylenic acid, erucic acid and nervonic acid, are inactive. The methyl esters and alcohol analogues of these compounds, glycerols, phospholipids, saturated fatty acids, retinoids and carotenes were inactive even at 0.2 mM. The results of the binding assay and the enzymic assay correlated well except for elaidic acid and linolelaidic acid, the trans isomers of oleic acid and linoleic acid respectively, which were much less active than their cis isomers in the binding assay but were as potent in the enzymic assay. gamma-Linolenic acid had no effect on the activities of two other rat liver microsomal enzymes: NADH:menadione reductase and glucuronosyl transferase. gamma-Linolenic acid, the most potent inhibitor tested, decreased the Vmax. and increased Km values of substrates, NADPH and testosterone, and promoted dissociation of [3H]4-MA from the microsomal reductase. gamma-Linolenic acid, but not the corresponding saturated fatty acid (stearic acid), inhibited the 5 alpha-reductase activity, but not the 17 beta-dehydrogenase activity, of human prostate cancer cells in culture. These results suggest that unsaturated fatty acids may play an important role in regulating androgen action in target cells. (AUTHOR)

  1. jamie10 added:

    nice info Gustav, I’ve just bought Emu oil. It contains just pure emu oil and lavender frangrance, it is high quality. It cost ?10.95 for a small 55 ml bottle.

    I got it off some website something like http://www.wwsm.co.uk

    I’ll let you know how it goes. I am using it on my arms where i have these little small pimples…
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  2. Gustav added:

    Androgen action in many organs, such as prostate and skin, is dependent on the conversion of testosterone by 5 alpha-reductase to 5 alpha-dihydrotestosterone. 5 alpha-Dihydrotestosterone then binds to the androgen receptor to regulate specific gene expression. Inhibitors of 5 alpha-reductase are useful for the selective treatment of prostatic cancer, benign prostate hyperplasia, acne, baldness and female hirsutism, without affecting spermatogenesis, sexual behavior and smooth muscle growth, that do not require the conversion of testosterone to 5 alpha-dihydrotestosterone. Certain unsaturated fatty acids, such as gamma-linolenic acid, are potent 5 alpha-reductase inhibitors, suggesting a linkage between unsaturated fatty acids and androgen action. Mutations in androgen receptor genes are responsible for many cases of androgen-insensitivity. In some prostate cancer cells, some antiandrogens may act like androgens in stimulating the proliferation of the cancer cells because these antiandrogens can bind to a mutated androgen receptor and transactivate target genes. Prostate cancers are usually androgen-dependent initially but can lose dependency and responsiveness. Tumor cells which are resistant to endocrine therapy ultimately proliferate. Androgen-independent or androgen-repressive cells can arise from androgen-sensitive prostate cancer cells by changes in specific gene expression over time in a clonal isolate. This change in androgen responsiveness was accompanied by a change in androgen receptor expression and transcriptional activity as well as expression of some oncogenes.

  3. Gustav added:

    Great site!

    http://www.emu-oil.com/

  4. Denise1 added:

    Probably why Acne Miracle’s topicals all have an emu oil base.

    I have been using emu oil for almost 6 months and love it. :)

  5. jamie10 added:

    Denise1:

    what are you using the emu oil for exactly?
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  6. Tracy76567 added:

    I’ve been using emu oil from this source. I LOVE THIS STUFF!!

    http://www.galaxymall.com/natural/emuoil

  7. jamie10 added:

    Okay so a lot of people love this stuff, but in what way?

    WHAT ARE YOU USING IT FOR?

    DRY SKIN?
    ACNE?
    RED MARKS?
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  8. Tracy76567 added:

    I use it as a moisturizer/anti-inflammatory. It also is a wonderful trans-dermal carrier and helps other topicals absorb deeper into the skin.

    You mix a few drops of it with either water or toner in your hands and pat on your face. It takes a little while to absorb but in the morning you’ll wake up with super-soft skin and it does not clog pores.

  9. mickeyinluv added:

    I also use a 100% pure, refined emu oil. I buy mine from http://www.emuoilshop.com I’ve been using it for a little more then a year now…and its simply wonderful!! a great moisturizer, in the long-run, it does help with pigmentation (in other words, should help with red marks). I also use an emu oil-based cream (100% natural) from http://www.purpleemu.com I wont lie, the cream’s pretty expensive… but It helped me in the long run…..my friends and relatives even notice a difference in my complexion and skin tone. I bought the 4oz emu oil bottle for about $16 or $17, but it lasted me close to a year!! (that is, if you’re only using it on ur face…I use it on my elbows and knees too to moisturize dryness) after washing my face, I put couple drops of emu oil on my palm, and apply it all over my face and neck. After few minutes (when its absorbed a little), I apply VERY VERY little bit of the cream, over the areas that have, had, or may get acne on…(mainly my cheeks and chin)

  10. SweetJade1980 added:

    Ok, now someone gets to educate me. I have heard about the wonders of emu oil and I’ve been tempted to use it in my hair to help it grow, but have been hesistant because I know that it comes from animals.

    So my question is, don’t they kill emus to get the oil? If they do kill the emus, are you buying from companies that use the ENTIRE animal, like emu jerky, etc? I don’t mind using animal products IF the entire animal is being used, otherwise I wouldn’t feel comfortable purchasing such a product, no matter how great it is.

    Thanks =)

  11. Tracy76567 added:

    Jade-

    I posed your questions to my emu oil source (denis baker emus). As soon as he gets back to me I’ll let you know.

  12. Denise1 added:

    I use it as a moisterizer at night on top of my Retin A. Leaves the skin like silk….

    Since it’s so strong in anti-inflammatory properties, a lot of people use it on muscle injuries. I got a pretty bad head injury about a month ago and literally had a knot the size of an egg (NO EXAGGERATION) right in between my eyes. I iced it for 45 mnutes and then put some emu oil on it and the swelling went right down.

    Maya’s son sprained his wrist a while ago and the emu oil took the swelling and pain away.

    So it’s good for many other uses; not just as a moisterizer or carrier oil, though it’s awesome for that, too. :D

  13. ev added:

    well.. you not using the product is still not gonna stop them from producing the oil … if it helps use it … we all struggle with ways to help our skin, and i do believe this will be a very good solution to all if used in combination with the right creams…

  14. jamie10 added:

    Do you think I can mix a bit of emu oil with BP to treat single pimples with?

    The emu oil I use is emu oil with a small amount of lavender fragrance…
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  15. Gustav added:

    Analysis of fatty acids in emu oil reveals that it contains approximately 70% unsaturated fatty acids. The major fatty acid found in emu oil is oleic acid, which is mono- unsaturated and which comprises over 40% of the total fatty acid contents. Emu oil also contains both of the two essential fatty acids (EFA’s) which are important to human health: 20% linoleic, and 1-2% alpha-linolenic acid.

    Testing using the rabbit ear histological assay, with emu oil in concentrations of 25%, 75% and 100% shows that emu oil in concentrations of up to 100% is non-comedogenic, i.e. it does not clog the pores of the skin.

    When compared with human skin oil, the fatty acid composition of emu oil is found to be quite similar. In both types of oil, mono-unsaturated oleic acid is the most prevalent fatty acid, followed by palmitic acid, then linoleic acid, which is an EFA. This similarity may be one of the factors enabling emu oil to have such a positive action on human skin.

  16. Gustav added:

    As I have shown there is 20% linoleic acid in Emu.

    Acne is characterized by hyperkeratosis of the follicular epithelium, leading to horny impactions that may lie dormant as open or closed comedones or may cause inflammation of the follicle. Although persons with acne have consistently been observed to have elevated levels of sebum secretion, no mechanism relating sebum secretion rates to comedogenesis is known. Acne patients have also been shown to have low levels of linoleic acid in their skin surface lipids. To explain this observation, the hypothesis is advanced that the linoleate concentration in human sebum depends on the quantity of linoleic acid present in each sebaceous cell at the commencement of its differentiation and on the extent to which this initial charge is diluted by subsequent endogenous lipid synthesis in each sebaceous cell. A corollary hypothesis holds that low concentrations of linoleate in sebum impose a state of essential fatty acid deficiency on the cells of the follicular epithelium and induce the characteristic response of hyperkeratosis. Both hypotheses could hold, without there being a systemic deficiency of linoleic acid, simply as the result of elevated lipogenesis in individual sebaceous cells.

    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2936775&dopt=Abstract

  17. Maya added:

    Ok, now someone gets to educate me. I have heard about the wonders of emu oil and I’ve been tempted to use it in my hair to help it grow, but have been hesistant because I know that it comes from animals.

    So my question is, don’t they kill emus to get the oil?
    Thanks =)

    Emu oil is a byproduct. Emus are farmed for their meat.

    From: http://www.aromatherapygiftshop.co.uk/Emu_Oil_Info.html

    Emu Oil Farming

    When the Australian government allowed Emu to be commercially farmed it established guidelines for farming and processing which exceeds those found for any other agricultural operation in the country After an initial authority to acquire minimal numbers of Emus from the wild to build up a breeding herd for the industry, restrictions were then placed on further use of wild birds Research quickly established successful breeding technology to allow for exponential increase of numbers. On average each pair of Emus produces 20-30 chicks each year. The Emus used for breeding are given well grassed and shaded fields to allow them to roam and to segregate into breeding pairs.

    The Emu farms are operated to a quality assurance programme with strict standards on fencing, population areas, shading and animal hygiene.Each farm is first thoroughly soil tested for the absence of chemicals and insecticides which were commonly used by past generations. After incubation of the Emu chicks, they are raised separately to protect them from the natural elements and predators. Artificial heating is available in the first month of their growth. Their diets which are free from chemicals, varies during their growth, but consists of grasses, herbage and grain.

    Emu Processing

    Emu is processed just like any other commercially bred and raised animal.

    From:
    An important environmental point is that Emu oil is derived from Emus being processed for their meat and not for their oil in other words it is a by-product which would simply be wasted had an application not been developed for it

    Processing facilities are controlled by the Australian Quarantine Inspection Service (AQIS) who have their own qualified veterinarian at the processing facilities at all times to ensure the processing is carried out in a humane manner and that the plant is operated to HACCP (Hazard Analysis Critical Control Point) standards. Ante and Post mortems are carried out on all Emus during processing. During the processing the Emu fat, which is found mainly on the back of the Emu, separated from the meat by a thin layer of tissue, is removed and immediately frozen to minus 20C for short term storage. The rendering of the Emu fat into oil is a critical operation to ensure that the special natural characteristics of the oil are preserved.

    The oil rendering plant used by Australian Emu Industries, AEI, (one of the world’s largest producers of Emu products and exclusive suppliers to the Aboriginoil brand) its the only plant in the world that is operated under strict HACCP guidelines to ensure the final oil product is of a standard suitable for therapeutic and food grade oil.

    The fat at the rendering plant is inspected to ensure it is free of inert matter. It is then heated at the correct temperature to maintain its beneficial antioxidants and to melt fat into oil. The oil is stored in drums in a temperature controlled environment. Analytical tests are carried out to analyse the fatty acid composition of the oil as well as chemical and bacterial tests to verify quality. With respect to our Aboriginoil at no stage during the refinery process has our oil been subjected to temperatures exceeding 300F. The oil is sterilised by holding it at 300F in the absence of oxygen, light and reactive materials. Typical physical properties at 20C for Aboriginoil is a semi-solid white cream coloured mass. At 60C it is clear, slightly straw tinted liquid with effectively no odour.

    The research seems to indictate that emu oil will improve hair growth by 20%.

  18. Gustav added:

    Comedonal lipids and skin surface lipids were collected from six acne patients and surface lipids were collected from sex- and age-matched controls without acne. Six series of ceramides were found in each sample, the relative amounts of which were determined by thin-layer chromatography/photodensitometry. Acylceramides (ceramide 1) were isolated by preparative thin-layer chromatography and their ester-linked fatty acids were analyzed by gas-liquid chromatography. The comedonal acylceramides contained higher proportions of 16:0, 16:1 delta 6, and 18:1 delta 6 + delta 8 and much less linoleate (18:2 delta 9,12) than the acylceramides from the skin surface. In the surface lipids from legs, acylceramides from the acne patients contained less linoleate than the acylceramides from control subjects. Free fatty acids from the comedones were also isolated and analyzed, and had a composition very similar to the esterified fatty acids of comedonal acylceramides. The results confirm that fatty acids derived from sebum become incorporated into comedonal acylceramides, displacing linoleate, and show that this process even affects the acylceramides of surface epidermis, more so in acne patients than in normal subjects.

    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2964492&dopt=Abstract

  19. Gustav added:

    WOW!! Now it gets interesting. It’s a must read!

    A major pathogenic factor of acne is the disturbed keratinization of the follicular infundibulum. It has been hypothesized that a relative decrease in linoleic acid in the sebum could be responsible, in part, for this. The aim of the present study was objectively to evaluate the effects of topically applied linoleic acid on the size of microcomedones in patients with mild acne. The design was a double-blind placebo-controlled randomized cross-over study. Evaluations were performed by digital image analysis of cyanoacrylate follicular biopsies. There was a significant effect of topically applied linoleic acid on the size of follicular casts and microcomedones, an almost 25% reduction in their overall size being achieved over a 1-month treatment period. In contrast, no change was found at placebo-treated sites. It is concluded that topical linoleic acid might play a role as a comedolytic agent in acne-prone patients.

  20. Tracy76567 added:

    Sweet Jade-

    Here is the response I received from my emu oil source (denis baker emus – http://www.galaxymall.com/natural/emuoil ):

    The answer to the first two question is yes. Emu Oil has been shown to help hair grow and is very good for the scalp. I think what happens is that the Emu Oil helps condition the scalp to such a degree that it makes for a much more conducive area to grow hair. This does take some time and regular use. It does not happen over night and the results do vary from person to person. The answer to next two questions is yes the Emu does have to be processed and the whole bird is definitely used. Meat, Hide and Oil are the products obtained from the Emu. You are familiar with the Oil so I will skip it. The meat is a very healthy red meat. Low in calories, low in fat and high in protein. It can be eaten in the form of steaks (similar to sirloin in beef), ground meat, jerky and snack sticks. Cooked properly it is very good. The hide makes a very nice leather similar to Ostrich. Not quite as durable and not quite as pronounced quill pattern as the Ostrich but very nice. Boots, shoes, purses, wallets, belts, etc., can all be made with the Emu hide. When an Emu is processed the whole bird can be used. Virtually none goes to waste. The Emu is an amazing bird. Hope this information has helped.

    I hope that helps you make your decision to use this really great oil. My 13 year old plays tackle football and he hurt his shoulder in practice last night. I put some emu oil on the shoulder and the pain and swelling went away and he was surprised that it didn’t hurt when he got ready for bed. This stuff is really amazing. Do some research and you’ll be glad you decided to use this stuff. Have a good day.

    Tracy

  21. Maya added:

    Yes, it’s great stuff!!!!!!!!!!!!!!!!!!!

  22. SweetJade1980 added:

    Wow, thanks everyone for responding to my question. =) Now I feel so much better about using this animal product.

    So what happened, why’d everyone stop posting here???

  23. msjenna added:

    I don’t know if anyone will respond, but if they do…Can anyone tell me if there is an oil that is similar in composition and effectiveness to emu that comes from plant source? Will jojoba have any effect? Thanks.

  24. Maya added:

    Personally I think that Jojoba oil is excellent so it’s fine to use instead of Emu oil. In my experience, jojoba oil is slightly better for oilier skins and emu is better fro drier skins. I mix them both! The emu oil is better when people are doing lots of exfoliation/peeling etc..

  25. SweetJade1980 added:

    right jojoba is supposed to be the closest thing or the next closest thing to our own skin oils. However, in terms of DHT inhibition, so far Emu Oil and other EFA containg oils are your best bests. Look for EPO, Borage, etc oils and if your skin can tolerate them, they could work as well.

    Good luck =)

  26. msjenna added:

    Will do. Thanks you two.